犬瘟热脑炎鞘内体液免疫反应的研究。
Studies on the intrathecal humoral immune response in canine distemper encephalitis.
作者信息
Vandevelde M, Zurbriggen A, Steck A, Bichsel P
出版信息
J Neuroimmunol. 1986 Mar;11(1):41-51. doi: 10.1016/0165-5728(86)90073-1.
Abstract
Albumin and IgG were quantitated in paired cerebrospinal fluid (CSF) and serum samples from dogs with demyelinating canine distemper virus (CDV) infection by means of rocket immunoelectrophoresis. The IgG index as indicator for intrathecal immunoglobulin synthesis was normal in animals with non-inflammatory demyelinating lesions and elevated in dogs with inflammatory myelin lesions. Specific antibodies against CDV and myelin were quantitated in CSF and serum from 8 dogs with an elevated IgG index. Eight of these dogs had significant amounts of antimyelin antibody and 4 dogs had neutralizing anti-CDV antibody in the CSF. Whereas the pathogenetic significance of antimyelin antibodies remains uncertain, the intrathecal antiviral immune response provides a plausible explanation for immunopathologic destruction of myelin in distemper.
摘要
采用火箭免疫电泳法对患有脱髓鞘犬瘟热病毒（CDV）感染的犬的配对脑脊液（CSF）和血清样本中的白蛋白和免疫球蛋白G（IgG）进行定量分析。作为鞘内免疫球蛋白合成指标的IgG指数，在患有非炎性脱髓鞘病变的动物中正常，而在患有炎性髓鞘病变的犬中升高。对8只IgG指数升高的犬的脑脊液和血清中针对CDV和髓磷脂的特异性抗体进行了定量分析。这些犬中有8只脑脊液中含有大量抗髓磷脂抗体，4只脑脊液中有中和性抗CDV抗体。虽然抗髓磷脂抗体的致病意义仍不确定，但鞘内抗病毒免疫反应为犬瘟热中髓磷脂的免疫病理破坏提供了一个合理的解释。
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