Yang Yuting, Thackray Alice E, Shen Tonghui, Alotaibi Tareq F, Alanazi Turki M, Clifford Tom, Hartescu Iuliana, King James A, Roberts Matthew J, Willis Scott A, Lolli Lorenzo, Atkinson Greg, Stensel David J
National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom.
School of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, China.
Sleep. 2025 Mar 11;48(3). doi: 10.1093/sleep/zsae250.
Using the necessary replicate-crossover design, we investigated whether there is interindividual variability in home-assessed sleep in response to acute exercise.
Eighteen healthy men (mean [SD]: 26[6] years) completed two identical control (8 hour laboratory rest, 08:45-16:45) and two identical exercise (7 hour laboratory rest; 1 hour laboratory treadmill run [62(7)% peak oxygen uptake], 15:15-16:15) trials in randomized sequences. Wrist-worn actigraphy (MotionWatch 8) measured home-based sleep (total sleep time, actual wake time, sleep latency, and sleep efficiency) two nights before (nights 1 and 2) and three nights after (nights 3-5) the exercise/control day. Pearson's correlation coefficients quantified the consistency of individual differences between the replicates of control-adjusted exercise responses to explore: (1) immediate (night 3 minus night 2); (2) delayed (night 5 minus night 2); and (3) overall (average post-intervention minus average pre-intervention) exercise-related effects. Within-participant linear mixed models and a random-effects between-participant meta-analysis estimated participant-by-trial response heterogeneity.
For all comparisons and sleep outcomes, the between-replicate correlations were nonsignificant, ranging from trivial to moderate (r range = -0.44 to 0.41, p ≥ .065). Participant-by-trial interactions were trivial. Individual differences SDs were small, prone to uncertainty around the estimates indicated by wide 95% confidence intervals, and did not provide support for true individual response heterogeneity. Meta-analyses of the between-participant, replicate-averaged condition effect revealed that, again, heterogeneity (τ) was negligible for most sleep outcomes.
Control-adjusted sleep in response to acute exercise was inconsistent when measured on repeated occasions. Interindividual differences in sleep in response to exercise were small compared with the natural (trial-to-trial) within-subject variability in sleep outcomes.
https://clinicaltrials.gov/study/NCT05022498. Registration number: NCT05022498.
采用必要的重复交叉设计，我们调查了急性运动后家庭评估睡眠中个体间是否存在变异性。
18名健康男性（平均[标准差]：26[6]岁）以随机顺序完成了两次相同的对照试验（8小时实验室休息，08:45 - 16:45）和两次相同的运动试验（7小时实验室休息；1小时实验室跑步机跑步[峰值摄氧量的62(7)%]，15:15 - 16:15）。在运动/对照日之前的两个晚上（第1和第2晚）以及之后的三个晚上（第3 - 5晚），使用腕部佩戴式活动记录仪（MotionWatch 8）测量家庭睡眠情况（总睡眠时间、实际清醒时间、睡眠潜伏期和睡眠效率）。Pearson相关系数量化了对照调整后的运动反应重复测量之间个体差异的一致性，以探究：(1) 即时（第3晚减去第2晚）；(2) 延迟（第5晚减去第2晚）；以及(3) 总体（干预后平均值减去干预前平均值）运动相关效应。参与者内线性混合模型和参与者间随机效应荟萃分析估计了每次试验的参与者反应异质性。
对于所有比较和睡眠结果，重复测量之间的相关性均不显著，范围从微不足道到中等（r范围 = -0.44至0.41，p≥0.065）。每次试验的参与者交互作用微不足道。个体差异标准差较小，95%置信区间较宽表明估计值周围存在不确定性，且不支持真正的个体反应异质性。参与者间重复测量平均条件效应的荟萃分析表明，同样，大多数睡眠结果的异质性（τ）可忽略不计。
在重复测量时，急性运动后对照调整的睡眠情况不一致。与睡眠结果中自然的（每次试验之间的）受试者内变异性相比，运动后睡眠的个体间差异较小。
https://clinicaltrials.gov/study/NCT05022498。注册号：NCT05022498。
