Tiwary Sajal, O'Neil Caroline A, Peacock Kate, Cass Candice, Amor Mostafa, Wallace Meghan A, McDonald David, Arter Olivia, Alvarado Kelly, Vogt Lucy, Stewart Henry, Park Daniel, Fraser Victoria J, Burnham Carey-Ann D, Farnsworth Christopher W, Kwon Jennie H
Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.
Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Antimicrob Steward Healthc Epidemiol. 2024 Oct 22;4(1):e184. doi: 10.1017/ash.2024.389. eCollection 2024.
To measure SARS-CoV-2 anti-nucleocapsid (anti-N) antibody seropositivity among healthcare personnel (HCP) without a history of COVID-19 and to identify HCP characteristics associated with seropositivity.
Prospective cohort study from September 22, 2020, to March 3, 2022.
A tertiary care academic medical center.
727 HCP without prior positive SARS-CoV-2 PCR testing were enrolled; 559 HCP successfully completed follow-up.
At enrollment and follow-up 1-6 months later, HCP underwent SARS-CoV-2 anti-N testing and were surveyed on demographics, employment information, vaccination status, and COVID-19 symptoms and exposures.
Of 727 HCP enrolled, 27 (3.7%) had a positive SARS-CoV-2 anti-N test at enrollment. Seropositive HCPs were more likely to have a household exposure to COVID-19 in the past 30 days (OR 7.92, 95% CI 2.44-25.73), to have had an illness thought to be COVID-19 (4.31, 1.94-9.57), or to work with COVID-19 patients more than half the time (2.09, 0.94-4.77). Among 559 HCP who followed-up, 52 (9.3%) had a positive SARS-CoV-2 anti-N antibody test result. Seropositivity at follow-up was associated with community/household exposures to COVID-19 within the past 30 days (9.50, 5.02-17.96; 2.90, 1.31-6.44), having an illness thought to be COVID-19 (8.24, 4.44-15.29), and working with COVID-19 patients more than half the time (1.50, 0.80-2.78).
Among HCP without prior positive SARS-CoV-2 testing, SARS-CoV-2 anti-N seropositivity was comparable to that of the general population and was associated with COVID-19 symptomatology and both occupational and non-occupational exposures to COVID-19.
检测无新冠病毒病（COVID-19）病史的医护人员（HCP）中严重急性呼吸综合征冠状病毒2（SARS-CoV-2）抗核衣壳（抗N）抗体血清阳性情况，并确定与血清阳性相关的医护人员特征。
2020年9月22日至2022年3月3日的前瞻性队列研究。
一家三级医疗学术医学中心。
纳入727名之前SARS-CoV-2核酸检测未呈阳性的医护人员；559名医护人员成功完成随访。
在入组时以及1至6个月后的随访时，医护人员接受SARS-CoV-2抗N检测，并接受关于人口统计学、就业信息、疫苗接种状况以及COVID-19症状和暴露情况的调查。
在纳入的727名医护人员中，27名（3.7%）在入组时SARS-CoV-2抗N检测呈阳性。血清阳性的医护人员在过去30天内家庭中更有可能接触过COVID-19（比值比[OR]7.92，95%置信区间[CI]2.44 - 25.73），更有可能患过疑似COVID-19的疾病（4.31，1.94 - 9.57），或者一半以上时间与COVID-19患者共事（2.09，0.94 - 4.77）。在559名完成随访的医护人员中，52名（9.3%）SARS-CoV-2抗N抗体检测结果呈阳性。随访时的血清阳性与过去30天内在社区/家庭中接触COVID-19（9.50，5.02 - 17.96；2.90，1.31 - 6.44）、患过疑似COVID-19的疾病（8.24，4.44 - 15.29）以及一半以上时间与COVID-19患者共事（1.50，0.80 - 2.78）有关。
在之前SARS-CoV-2检测未呈阳性的医护人员中，SARS-CoV-2抗N血清阳性率与普通人群相当，且与COVID-19症状以及职业和非职业性接触COVID-19有关。
