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探索利用天然提取物绿色合成银纳米颗粒及其在癌症治疗中的潜力。

Exploring the green synthesis of silver nanoparticles using natural extracts and their potential for cancer treatment.

作者信息

Abdellatif Ahmed A H, Mostafa Mahmoud A H, Konno Hiroyuki, Younis Mahmoud A

机构信息

Department of Pharmaceutics, College of Pharmacy, Qassim University, 51452 Al Qassim, Saudi Arabia.

Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, 41477 Al Madinah, Al Munawarah Saudi Arabia.

出版信息

3 Biotech. 2024 Nov;14(11):274. doi: 10.1007/s13205-024-04118-z. Epub 2024 Oct 23.

Abstract

Silver nanoparticles (AgNPs) have attracted increasing attention in nanomedicine, with versatile applications in drug delivery, antimicrobial treatments, and cancer therapies. While chemical synthesis remains a common approach for AgNP production, ensuring environmental sustainability requires a shift toward eco-friendly, "green" synthesis techniques. This article underscores the promising role of plant extracts in the green synthesis of AgNPs, highlighting the importance of their natural sources and diverse bioactive compounds. Various characterization methods for these nanomaterials are also reviewed. Furthermore, the anticancer potential of green AgNPs (Gr-AgNPs) is examined, focusing on their mechanisms of action and the challenges to their clinical implementation. Finally, future directions in the field are discussed.

摘要

银纳米颗粒(AgNPs)在纳米医学领域引起了越来越多的关注,在药物递送、抗菌治疗和癌症治疗等方面有着广泛的应用。虽然化学合成仍然是生产AgNPs的常用方法,但要确保环境可持续性,就需要转向环保的“绿色”合成技术。本文强调了植物提取物在AgNPs绿色合成中的潜在作用,突出了其天然来源和多种生物活性化合物的重要性。还综述了这些纳米材料的各种表征方法。此外,研究了绿色银纳米颗粒(Gr-AgNPs)的抗癌潜力,重点关注其作用机制以及临床应用面临的挑战。最后,讨论了该领域的未来发展方向。

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