National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China.
Hubei International Scientific and Technological Cooperation Base of Veterinary Epidemiology, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, People's Republic of China.
Emerg Microbes Infect. 2024 Dec;13(1):2417859. doi: 10.1080/22221751.2024.2417859. Epub 2024 Nov 11.
Brucellosis, caused by several species of , continues to be a significant illness that poses a global threat to public health. China remains a persistent hotspot for brucellosis, despite the implementation of extensive control measures. This study aims to conduct a systematic review and meta-analysis of the seroprevalence of bovine brucellosis in different breeds and regions of China from 2014-2024, and to provide predictions on the future prevalence patterns of brucellosis in cattle and humans. The analysis comprised a total of 80 research studies, which consisted of 187 datasets and a combined sample size of 3,130,706. We estimated the overall pooled seroprevalence of bovine brucellosis in China to be 1.5% (95% CI: 0.6-2.6%). Subgroup analysis revealed that the seroprevalence in dairy cattle was 3.1%, surpassing the seroprevalence in beef cattle (1.3%) and yak (1.5%). Regions that had authorized vaccination programmes exhibited higher seroprevalence (1.8%) compared to regions that did not have vaccination (0.5%). Notably, the study observed a simultaneous rise in both the prevalence of brucellosis in cattle and the number of human brucellosis cases. This suggests that high-quality routine surveillance of brucellosis in cattle will be essential for predicting and responding to cases in humans. Additionally, given the existing prevention and control measures, brucellosis will likely continue to be prevalent in both cattle and people. This systematic review will assist policymakers in adjusting animal surveillance and interregional livestock movement policies, ultimately contributing to the public safety goal of preventing brucellosis in humans by controlling it in animals.
布鲁氏菌病是由几种 引起的，仍然是对全球公共卫生构成重大威胁的一种严重疾病。尽管实施了广泛的控制措施，中国仍然是布鲁氏菌病的持续热点地区。本研究旨在对 2014 年至 2024 年中国不同品种和地区牛布鲁氏菌病的血清流行率进行系统评价和荟萃分析，并对未来牛和人类布鲁氏菌病的流行模式进行预测。该分析共包括 80 项研究，其中包含 187 个数据集，综合样本量为 3130706 个。我们估计中国牛布鲁氏菌病的总血清流行率为 1.5%（95%置信区间：0.6-2.6%）。亚组分析显示，奶牛的血清流行率为 3.1%，高于肉牛（1.3%）和牦牛（1.5%）的血清流行率。有授权疫苗接种计划的地区的血清流行率（1.8%）高于没有疫苗接种的地区（0.5%）。值得注意的是，研究观察到牛布鲁氏菌病的流行率和人类布鲁氏菌病病例数同时上升。这表明，对牛布鲁氏菌病进行高质量的常规监测对于预测和应对人类病例至关重要。此外，鉴于现有的预防和控制措施，牛和人都可能继续存在布鲁氏菌病。本系统评价将有助于政策制定者调整动物监测和区域间牲畜流动政策，最终通过控制动物来实现预防人类布鲁氏菌病的公共安全目标。
