Hung Man, Sadri Mahsa, Katz Melanie, Schwartz Connor, Mohajeri Amir
College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA.
Division of Public Health, University of Utah, Salt Lake City, UT 84108, USA.
Dent J (Basel). 2024 Sep 29;12(10):315. doi: 10.3390/dj12100315.
Regenerative medicine is revolutionizing oral and maxillofacial surgeries with stem cells, particularly mesenchymal stem cells, for tissue and bone regeneration. Despite promising results, human trials are limited. A systematic review is needed to evaluate stem cell efficacy in maxillofacial issues, aiming to improve surgical outcomes and patient satisfaction.
Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses Guidelines, this review included peer-reviewed articles (2013-2023) on stem cells in oral surgery, excluding non-English publications, abstracts, reviews, and opinion pieces. Searches were conducted in PubMed, Web of Science, OVID, Cochrane, Dentistry & Oral Sciences Source-Ebscohost, and Scopus. Two authors independently screened titles and abstracts, resolving disagreements by consensus. Full-text analysis involved extracting key data, verified by a secondary reviewer and additional quality checks.
From 3540 initial articles, 2528 were screened after removing duplicates, and 7 met the inclusion criteria after excluding irrelevant studies. Key themes included the safety and efficacy of stem cell therapy, and bone regeneration and quality. Studies predominantly used mesenchymal stem cells. Findings showed positive outcomes in clinical safety and effectiveness and significant potential for bone regeneration.
This systematic review highlights the potential of stem cell therapies in maxillofacial applications, supporting their safety, efficacy, and bone regeneration capabilities. Further research is needed to standardize protocols and confirm long-term benefits.
再生医学正在用干细胞，尤其是间充质干细胞，彻底改变口腔颌面外科手术，用于组织和骨再生。尽管取得了令人鼓舞的成果，但人体试验仍然有限。需要进行系统综述来评估干细胞在颌面问题中的疗效，旨在改善手术效果和患者满意度。
按照系统评价和Meta分析的首选报告项目指南，本综述纳入了2013年至2023年关于口腔外科干细胞的同行评审文章，排除非英文出版物、摘要、综述和观点文章。检索在PubMed、科学网、OVID、Cochrane、牙科学与口腔科学源-Ebscohost和Scopus中进行。两位作者独立筛选标题和摘要，通过共识解决分歧。全文分析包括提取关键数据，由第二位评审员进行验证并进行额外的质量检查。
从3540篇初始文章中，去除重复文章后筛选出2528篇，排除无关研究后7篇符合纳入标准。关键主题包括干细胞治疗的安全性和有效性以及骨再生和质量。研究主要使用间充质干细胞。研究结果显示临床安全性和有效性有积极结果，骨再生潜力巨大。
本系统综述突出了干细胞疗法在颌面应用中的潜力，支持其安全性、有效性和骨再生能力。需要进一步研究来规范方案并确认长期益处。
