2020年至2022年加拿大艾伯塔省南部产志贺毒素大肠杆菌（STEC）的临床结果及毒力因子
Clinical Outcomes and Virulence Factors of Shiga Toxin-Producing (STEC) from Southern Alberta, Canada, from 2020 to 2022.
作者信息
Glassman Heather, Suttorp Vivien, White Theron, Ziebell Kim, Kearney Ashley, Bessonov Kyrylo, Li Vincent, Chui Linda
机构信息
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Medical Officer of Health, Alberta Health Services, Lethbridge, AB T1J 4E1, Canada.
出版信息
Pathogens. 2024 Sep 24;13(10):822. doi: 10.3390/pathogens13100822.
Shiga toxin-producing (STEC) can cause severe clinical disease in humans, particularly in young children. Recent advances have led to greater availability of sequencing technologies. We sought to use whole genome sequencing data to identify the presence or absence of known virulence factors in all clinical isolates submitted to our laboratory from Southern Alberta dated 2020-2022 and correlate these virulence factors with clinical outcomes obtained through chart review. Overall, the majority of HUS and hospitalizations were seen in patients with O157:H7 serotypes, and HUS cases were primarily in young children. The frequency of virulence factors differed between O157:H7 and non-O157 serotypes. Within the O157:H7 cases, certain virulence factors, including , , and , were more frequent in HUS cases. The number of samples was too low to determine statistical significance.
产志贺毒素大肠杆菌（STEC）可导致人类出现严重临床疾病，尤其是年幼儿童。近期的进展使测序技术的可及性更高。我们试图利用全基因组测序数据，确定2020年至2022年提交至我们实验室的来自阿尔伯塔省南部的所有临床分离株中已知毒力因子的有无，并将这些毒力因子与通过病历审查获得的临床结果相关联。总体而言，大多数溶血尿毒综合征（HUS）病例和住院病例见于O157:H7血清型患者，且HUS病例主要为年幼儿童。O157:H7和非O157血清型的毒力因子频率有所不同。在O157:H7病例中，某些毒力因子，包括[此处原文缺失具体毒力因子名称]，在HUS病例中更为常见。样本数量过少，无法确定统计学意义。
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