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Targeting CBP revers chemoresistance to 5-FU of CDX2/REG4 double-positive gastric cancer.

作者信息

Fan Zhiyuan, Li Fangyuan, Jiang Xiao, Pan Tao, Zang Mingde, Li Jianfang, Yu Beiqin, Sang Qingqing, Liu Wentao, Su Liping, Li Chen, Zhu Zhenggang, Yan Min, Yan Chao, Yuan Fei, Liu Bingya

机构信息

Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Department of Breast Surgery, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

出版信息

Clin Transl Med. 2024 Nov;14(11):e70069. doi: 10.1002/ctm2.70069.

DOI:10.1002/ctm2.70069
PMID:39456121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11511671/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be5a/11511671/3a8cb9b31110/CTM2-14-e70069-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be5a/11511671/b6238583fe28/CTM2-14-e70069-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be5a/11511671/6e19c77e5077/CTM2-14-e70069-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be5a/11511671/b7dc016b6e5b/CTM2-14-e70069-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be5a/11511671/3a8cb9b31110/CTM2-14-e70069-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be5a/11511671/b6238583fe28/CTM2-14-e70069-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be5a/11511671/6e19c77e5077/CTM2-14-e70069-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be5a/11511671/b7dc016b6e5b/CTM2-14-e70069-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be5a/11511671/3a8cb9b31110/CTM2-14-e70069-g002.jpg

相似文献

1
Targeting CBP revers chemoresistance to 5-FU of CDX2/REG4 double-positive gastric cancer.靶向CBP可逆转CDX2/REG4双阳性胃癌对5-氟尿嘧啶的化疗耐药性。
Clin Transl Med. 2024 Nov;14(11):e70069. doi: 10.1002/ctm2.70069.
2
Regenerating Family Member 4 (Reg4) Enhances 5-Fluorouracil Resistance of Gastric Cancer Through Activating MAPK/Erk/Bim Signaling Pathway.再生家族成员4（Reg4）通过激活MAPK/Erk/Bim信号通路增强胃癌对5-氟尿嘧啶的耐药性。
Med Sci Monit. 2017 Jul 31;23:3715-3721. doi: 10.12659/msm.903134.
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REG4 is associated with carcinogenesis in the 'intestinal' pathway of intraductal papillary mucinous neoplasms.REG4与导管内乳头状黏液性肿瘤的“肠型”癌变途径相关。
Mod Pathol. 2009 Mar;22(3):460-8. doi: 10.1038/modpathol.2008.205. Epub 2009 Jan 9.
4
Regulation of Expression and Prediction of 5-Fluorouracil Sensitivity by CDX2 in Ovarian Mucinous Carcinoma.CDX2 对卵巢黏液性癌中 5-氟尿嘧啶敏感性的表达调控及预测。
Cancer Genomics Proteomics. 2019 Nov-Dec;16(6):481-490. doi: 10.21873/cgp.20151.
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Single-chain Antibody Against Reg4 Suppresses Gastric Cancer Cell Growth and Enhances 5-FU-induced Cell Death in vitro.抗 Reg4 单链抗体抑制胃癌细胞生长并增强体外 5-FU 诱导的细胞死亡。
Anticancer Agents Med Chem. 2019;19(5):610-619. doi: 10.2174/1871520619666181122104720.
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The effects of REG4 expression on chemoresistance of ovarian cancer.REG4表达对卵巢癌化疗耐药性的影响。
J Obstet Gynaecol. 2022 Oct;42(7):3149-3157. doi: 10.1080/01443615.2022.2106834. Epub 2022 Aug 5.
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Reg IV is a direct target of intestinal transcriptional factor CDX2 in gastric cancer.Reg IV 是胃癌中肠道转录因子 CDX2 的直接靶标。
PLoS One. 2012;7(11):e47545. doi: 10.1371/journal.pone.0047545. Epub 2012 Nov 2.
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Regenerating gene 4 promotes chemoresistance of colorectal cancer by affecting lipid droplet synthesis and assembly.再生基因 4 通过影响脂滴的合成和组装促进结直肠癌的化疗耐药性。
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Expression of REG4 in ovarian mucinous tumors.REG4在卵巢黏液性肿瘤中的表达。
Appl Immunohistochem Mol Morphol. 2014 Apr;22(4):295-301. doi: 10.1097/PAI.0b013e3182936d8e.
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The Clinical Significance and Mechanisms of REG4 in Human Cancers.REG4在人类癌症中的临床意义及机制
Front Oncol. 2021 Jan 8;10:559230. doi: 10.3389/fonc.2020.559230. eCollection 2020.

本文引用的文献

1
Analysis and therapeutic targeting of the EP300 and CREBBP acetyltransferases in anaplastic large cell lymphoma and Hodgkin lymphoma.分析和治疗靶向 EP300 和 CREBBP 乙酰转移酶在间变大细胞淋巴瘤和霍奇金淋巴瘤中的作用。
Leukemia. 2023 Feb;37(2):396-407. doi: 10.1038/s41375-022-01774-z. Epub 2022 Dec 1.
2
Histone acetyltransferases CBP/p300 in tumorigenesis and CBP/p300 inhibitors as promising novel anticancer agents.组蛋白乙酰转移酶 CBP/p300 在肿瘤发生中的作用及 CBP/p300 抑制剂作为有前途的新型抗癌药物。
Theranostics. 2022 Jun 21;12(11):4935-4948. doi: 10.7150/thno.73223. eCollection 2022.
3
Immunohistochemical Expression of CDX2 in Gastric Carcinoma.
CDX2在胃癌中的免疫组化表达
Iran J Pathol. 2022 Spring;17(2):143-149. doi: 10.30699/IJP.2022.530631.2648. Epub 2022 Mar 8.
4
Targeting both BET and CBP/EP300 proteins with the novel dual inhibitors NEO2734 and NEO1132 leads to anti-tumor activity in multiple myeloma.新型双重抑制剂 NEO2734 和 NEO1132 靶向 BET 和 CBP/EP300 蛋白，可在多发性骨髓瘤中发挥抗肿瘤活性。
Eur J Haematol. 2021 Jan;106(1):90-99. doi: 10.1111/ejh.13525. Epub 2020 Oct 22.
5
Regulation of Expression and Prediction of 5-Fluorouracil Sensitivity by CDX2 in Ovarian Mucinous Carcinoma.CDX2 对卵巢黏液性癌中 5-氟尿嘧啶敏感性的表达调控及预测。
Cancer Genomics Proteomics. 2019 Nov-Dec;16(6):481-490. doi: 10.21873/cgp.20151.
6
Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome.时间分辨分析揭示了 CBP/p300 乙酰基组的快速动态和广泛范围。
Cell. 2018 Jun 28;174(1):231-244.e12. doi: 10.1016/j.cell.2018.04.033. Epub 2018 May 24.
7
GPS-PAIL: prediction of lysine acetyltransferase-specific modification sites from protein sequences.GPS-PAIL：从蛋白质序列预测赖氨酸乙酰转移酶特异性修饰位点。
Sci Rep. 2016 Dec 22;6:39787. doi: 10.1038/srep39787.
8
Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).基于片段的选择性细胞活性苯二氮卓酮CBP/EP300溴结构域抑制剂（CPI-637）的发现
ACS Med Chem Lett. 2016 Mar 15;7(5):531-6. doi: 10.1021/acsmedchemlett.6b00075. eCollection 2016 May 12.
9
Reg IV is a direct target of intestinal transcriptional factor CDX2 in gastric cancer.Reg IV 是胃癌中肠道转录因子 CDX2 的直接靶标。
PLoS One. 2012;7(11):e47545. doi: 10.1371/journal.pone.0047545. Epub 2012 Nov 2.
10
Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles.EVI1与环磷酸腺苷反应元件结合蛋白结合蛋白（CBP）和p300/CBP相关因子（P/CAF）的相互作用导致EVI1发生可逆性乙酰化，并在核斑点中共定位。
J Biol Chem. 2001 Nov 30;276(48):44936-43. doi: 10.1074/jbc.M106733200. Epub 2001 Sep 21.