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发酵药用物质，一种通过显著的抗氧化和抗炎作用改善代谢状况的功能性食品。

Massa Medicata Fermentata, a Functional Food for Improving the Metabolic Profile via Prominent Anti-Oxidative and Anti-Inflammatory Effects.

作者信息

Jung Kyung-Mi, Yu Ga-Ram, Kim Da-Hoon, Lim Dong-Woo, Park Won-Hwan

机构信息

Department of Diagnostics, College of Korean Medicine, Dongguk University, Goyang-si 10326, Republic of Korea.

Institute of Korean Medicine, Dongguk University, Goyang-si 10326, Republic of Korea.

出版信息

Antioxidants (Basel). 2024 Oct 19;13(10):1271. doi: 10.3390/antiox13101271.

DOI:10.3390/antiox13101271
PMID:39456523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11504248/
Abstract

Massa Medicata Fermentata (MMF) is a naturally fermented product used to treat indigestion and increase stomach activity in traditional medicine. This study examined the ability of the hydrothermal extract of MMF to scavenge free radicals corresponding to biological oxidative stresses, further protecting essential biomolecules. The anti-inflammatory effects of MMF were evaluated in LPS-induced RAW264.7 macrophages and zebrafish. In addition, the effects of MMF on the body mass index (BMI) and cholesterol accumulation in adult zebrafish fed a high-cholesterol diet (HCD) for three weeks were examined. MMF prevented the DNA and lipid damage caused by oxidative stress, inhibited LDL oxidation, and reduced the expression of cytokines and related proteins (MAPK and NFκB), with prominent anti-oxidative pathway (NRF2-HO-1) activation properties. LPS-induced NO production was reduced, and the increase in BMI and TC caused by the HCD diet was suppressed by MMF in zebrafish embryos or adult zebrafish. The bioactive aglycone of quercetin may be contributing to the mechanisms of systemic effects. MMF has excellent antioxidant properties and is useful for improving inflammation status and metabolic profile, thus highlighting its potential as a healthy, functional food.

摘要

神曲是一种天然发酵产物，在传统医学中用于治疗消化不良和增强胃动力。本研究检测了神曲水热提取物清除与生物氧化应激相关自由基的能力，进一步保护重要生物分子。在脂多糖诱导的RAW264.7巨噬细胞和斑马鱼中评估了神曲的抗炎作用。此外，还研究了神曲对喂食高胆固醇饮食（HCD）三周的成年斑马鱼体重指数（BMI）和胆固醇积累的影响。神曲可预防氧化应激引起的DNA和脂质损伤，抑制低密度脂蛋白氧化，并降低细胞因子和相关蛋白（丝裂原活化蛋白激酶和核因子κB）的表达，具有显著的抗氧化途径（核因子E2相关因子2-血红素加氧酶-1）激活特性。在斑马鱼胚胎或成年斑马鱼中，神曲可降低脂多糖诱导的一氧化氮生成，并抑制HCD饮食引起的BMI和总胆固醇升高。槲皮素的生物活性苷元可能是其全身作用机制的原因。神曲具有优异的抗氧化性能，有助于改善炎症状态和代谢状况凸显了其作为健康功能性食品的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/11504248/a99b964b61e9/antioxidants-13-01271-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/11504248/71bdfa2f9ef7/antioxidants-13-01271-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/11504248/a6633f7d42b8/antioxidants-13-01271-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/11504248/fa8e2d3e5769/antioxidants-13-01271-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/11504248/e06c089c68c1/antioxidants-13-01271-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/11504248/69456d412bcf/antioxidants-13-01271-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/11504248/ecf6f830e6c4/antioxidants-13-01271-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/11504248/40908826ad3c/antioxidants-13-01271-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/11504248/b0f64b562461/antioxidants-13-01271-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/11504248/a99b964b61e9/antioxidants-13-01271-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/11504248/71bdfa2f9ef7/antioxidants-13-01271-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/11504248/a6633f7d42b8/antioxidants-13-01271-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/11504248/fa8e2d3e5769/antioxidants-13-01271-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/11504248/e06c089c68c1/antioxidants-13-01271-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/11504248/69456d412bcf/antioxidants-13-01271-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/11504248/ecf6f830e6c4/antioxidants-13-01271-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/11504248/40908826ad3c/antioxidants-13-01271-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/11504248/b0f64b562461/antioxidants-13-01271-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/11504248/a99b964b61e9/antioxidants-13-01271-g009.jpg

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