Neagoe Cara-Xenia-Rafaela, Ionică Mihaela, Neagoe Octavian Constantin, Trifa Adrian Pavel
Doctoral School, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania.
Second Clinic of General Surgery and Surgical Oncology, Emergency Clinical Municipal Hospital, 300079 Timișoara, Romania.
Cancers (Basel). 2024 Oct 13;16(20):3468. doi: 10.3390/cancers16203468.
Breast cancer remains one of the leading causes of death among women worldwide, and recent research highlights its growing connection to alterations in the microbiota. This review delves into the intricate relationship between microbiotas and breast cancer, exploring its presence in healthy breast tissue, its changes during cancer progression, and its considerable impact on both the tumor microenvironment (TME) and the tumor immune microenvironment (TIME). We extensively analyze how the microbiota influences cancer growth, invasion, metastasis, resistance to drugs, and the evasion of the immune system, with a special focus on its effects on the TIME. Furthermore, we investigate distinct microbial profiles associated with the four primary molecular subtypes of breast cancer, examining how the microbiota in tumor tissues compares with that in adjacent normal tissues. Emerging studies suggest that microbiotas could serve as valuable diagnostic and prognostic biomarkers, as well as targets for therapy. This review emphasizes the urgent need for further research to improve strategies for breast cancer prevention, diagnosis, and treatment. By offering a detailed examination of the microbiota's critical role in breast cancer, this review aims to foster the development of novel microbiota-based approaches for managing the disease.
乳腺癌仍然是全球女性主要死因之一，近期研究凸显了其与微生物群改变之间日益紧密的联系。本综述深入探讨微生物群与乳腺癌之间的复杂关系，探究其在健康乳腺组织中的存在情况、癌症进展过程中的变化，以及对肿瘤微环境（TME）和肿瘤免疫微环境（TIME）的重大影响。我们广泛分析微生物群如何影响癌症的生长、侵袭、转移、耐药性以及免疫系统逃逸，特别关注其对TIME的影响。此外，我们研究与乳腺癌四种主要分子亚型相关的不同微生物谱，考察肿瘤组织中的微生物群与相邻正常组织中的微生物群有何不同。新兴研究表明，微生物群可作为有价值的诊断和预后生物标志物，以及治疗靶点。本综述强调迫切需要进一步研究，以改进乳腺癌的预防、诊断和治疗策略。通过详细审视微生物群在乳腺癌中的关键作用，本综述旨在推动基于微生物群的新型疾病管理方法的发展。
