Institut Recerca Sant Pau, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain.
School of Pharmacy and Food Sciences, University of Barcelona (UB), 08036 Barcelona, Spain.
Nutrients. 2024 Oct 18;16(20):3541. doi: 10.3390/nu16203541.
: Growing evidence suggests that erythrocyte membrane lipids are subject to changes during their lifespan. Factors such as the type of dietary intake and its composition contribute to the changes in red blood cell (RBC) membranes. Due to the high antioxidant content of beer, we aimed to investigate the effect of moderate beer consumption on the lipid composition of RBCs membranes from healthy overweight individuals. : We conducted a four-weeks, prospective two-arm longitudinal crossed-over study, where participants ( = 36) were randomly assigned to alcohol-free beer group or traditional beer group. The lipids of RBCs membranes were assessed at the beginning and the end of the intervention by thin-layer chromatography. : Four-weeks of alcohol-free beer promoted changes in fatty acids (FA), free cholesterol (FC), phosphatidylethanolamine (PE) and phosphatidylcholine (PC) ( < 0.05). Meanwhile, traditional beer intake led to changes in FA, FC, phospholipids (PL), PE and PC ( < 0.05). The observed alterations in membrane lipids were found to be independent of sex and BMI as influencing factors. : The lipid composition of erythrocyte membranes is distinctly but mildly influenced by the consumption of both non-alcoholic and conventional beer, with no effects on RBC membrane fluidity.
越来越多的证据表明，红细胞膜脂质在其寿命期间会发生变化。饮食类型及其组成等因素导致红细胞（RBC）膜发生变化。由于啤酒具有高抗氧化含量，我们旨在研究适量饮用啤酒对健康超重个体 RBC 膜脂质组成的影响。
我们进行了为期四周的前瞻性双臂纵向交叉研究，其中参与者（n=36）被随机分配到无酒精啤酒组或传统啤酒组。通过薄层色谱法在干预开始和结束时评估 RBC 膜的脂质。
四周的无酒精啤酒促进了脂肪酸（FA）、游离胆固醇（FC）、磷脂酰乙醇胺（PE）和磷脂酰胆碱（PC）的变化（<0.05）。同时，传统啤酒摄入导致 FA、FC、磷脂（PL）、PE 和 PC 发生变化（<0.05）。观察到的膜脂质变化不受性别和 BMI 等影响因素的影响。
红细胞膜的脂质组成受非酒精和传统啤酒的消费明显但轻微的影响，对 RBC 膜流动性没有影响。
