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使用磁性纳米颗粒和微流控技术的小型化病原体检测系统

Miniaturized Pathogen Detection System Using Magnetic Nanoparticles and Microfluidics Technology.

作者信息

Garlan Benjamin, Rabehi Amine, Ngo Kieu, Neveu Sophie, Askari Moghadam Reza, Kokabi Hamid

机构信息

Group of Electrical Engineering of Paris (GeePs), Sorbonne Université, CNRS UMR8507, 75005 Paris, France.

Laboratoire de Réactivité de Surface, LRS, Sorbonne Université, UMR CNRS 7197, 75252 Paris, France.

出版信息

Micromachines (Basel). 2024 Oct 20;15(10):1272. doi: 10.3390/mi15101272.

DOI:10.3390/mi15101272
PMID:39459146
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11509726/
Abstract

Rapid detection of a biological agent is essential to anticipate a threat to the protection of biodiversity and ecosystems. Our goal is to miniaturize a magnetic pathogen detection system in order to fabricate an efficient and portable system. The detection device is based on flat, multilayer coils associated with microfluidic structures to detect magnetic nanoparticles linked to pathogen agents. One type of immunological diagnosis is based on the measurement of the magnetic sensitivity of magnetic nanoparticles (MNPs), which are markers connected to pathogens. This method of analysis involves the coupling of antibodies or antigen proteins with MNPs. Among the available magnetic techniques, the frequency mixing method has a definite advantage by making it possible to quantify MNPs. An external magnetic field composed of a low- and a high-frequency field is applied to the sample reservoir. Then, the response signal is measured and analyzed. In this paper, magnetic microcoils are implemented on a multilayer Printed Circuit Board (PCB), and a microfluidics microstructure is designed in connection with the planar coils. Simulation software, COMSOL version 5.3, provides an analytical perspective to choose the number of turns in magnetic coils and to understand the effects of changing the shape and dimensions of the microfluidics microstructure.

摘要

快速检测生物制剂对于预测对生物多样性和生态系统保护的威胁至关重要。我们的目标是将磁性病原体检测系统小型化，以制造出高效且便携的系统。该检测装置基于与微流体结构相关联的扁平多层线圈，用于检测与病原体试剂相连的磁性纳米颗粒。一种免疫诊断类型基于对磁性纳米颗粒（MNP）磁敏感性的测量，这些磁性纳米颗粒是与病原体相连的标记物。这种分析方法涉及抗体或抗原蛋白与MNP的偶联。在现有的磁性技术中，频率混合方法具有明显优势，因为它能够对MNP进行定量。将由低频和高频场组成的外部磁场施加到样品池中。然后，对响应信号进行测量和分析。在本文中，磁性微线圈被应用于多层印刷电路板（PCB）上，并且结合平面线圈设计了微流体微观结构。仿真软件COMSOL版本5.3提供了一个分析视角，用于选择磁性线圈的匝数，并了解改变微流体微观结构的形状和尺寸所产生的影响。

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