Briand Clémence, Gourier Greta, Poizeau Florence, Jelti Lamia, Bachelerie Marie, Quéreux Gaëlle, Jeudy Géraldine, Acquitter Marie, Ingen-Housz-Oro Saskia, Caux Frédéric, Prost Catherine, Darrigade Anne-Sophie, Heron Mermin Diane, Mahé Emmanuel, Picart Dahan Catherine, Richard Marie-Aleth, Clerc Caroline Jade, Salle De Chou Camille, Plée Julie, Abasq-Thomas Claire, Misery Laurent, Brenaut Emilie
Department of Dermatology, Centre Hospitalier Universitaire (CHU) Brest, FR-29609 Brest, France. E-mail:
Acta Derm Venereol. 2020 Nov 12;100(18):adv00320. doi: 10.2340/00015555-3683.
Pruritus is a common symptom of bullous pemphigoid (BP), but has been poorly studied. The aim of this study was to analyse the characteristics of pruritus in patients with BP and its impact on their quality of life. A multicentre prospective observational study (in 15 French hospitals) was performed. A total of 60 patients were included, with a mean age of 77.4 years. Pruritus occurred daily in 85% of patients, with a mean pruritus intensity of 5.2/10. Tingling sensations were present in 72.4% of patients and burning sensations in 68.9%. Pruritus was exacerbated by stress, fatigue and xerosis. The mean ItchyQol score was 56.2/110 and the mean 5-D Itch Scale score was 16.5/25. The severity of pruritus was not related to age, sex, BP activity score, eosinophilia, or anti-BP230 and anti-BP180 autoantibodies. This study revealed that pruritus in BP is poorly tolerated and is an important cause of impaired quality of life.
瘙痒是大疱性类天疱疮（BP）的常见症状，但相关研究较少。本研究旨在分析BP患者瘙痒的特征及其对生活质量的影响。开展了一项多中心前瞻性观察研究（在15家法国医院进行）。共纳入60例患者，平均年龄77.4岁。85%的患者每天都有瘙痒，平均瘙痒强度为5.2/10。72.4%的患者有刺痛感，68.9%的患者有烧灼感。压力、疲劳和皮肤干燥会加重瘙痒。瘙痒症生活质量（ItchyQol）平均评分为56.2/110，5维瘙痒量表平均评分为16.5/25。瘙痒的严重程度与年龄、性别、BP活动评分、嗜酸性粒细胞增多症或抗BP230和抗BP180自身抗体无关。本研究表明，BP患者的瘙痒耐受性差，是生活质量受损的重要原因。
