Reply to the Comments on "Biomarkers and Related Factors for the Diagnosis, Risk of Coronary Artery Lesions, and Resistance to Intravenous Immunoglobulin in Kawasaki Disease: An Umbrella Review of Meta-Analyses".

The article "Biomarkers and related factors for the diagnosis, risk of coronary artery lesions, and resistance to intravenous immunoglobulin in Kawasaki disease: an umbrella review of meta-analyses" offers valuable insights into diagnostic and therapeutic settings by overviewing various biomarkers associated with Kawasaki disease. There are some comments related to our umbrella review methodology, particularly PRIOR guidelines and GRADE framework. We clarify our choice of the PRISMA 2020 guidelines over PRIOR and explain the rigorous methodology used, which aligns with GRADE principles, ensuring robust and reliable findings. In addition, we address the suggestion for sensitivity analysis, noting that potential biases were managed through AMSTAR2 assessments, heterogeneity testing, and publication bias analysis.