College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao 266071, China.
State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao 266071, China.
Adv Colloid Interface Sci. 2024 Dec;334:103317. doi: 10.1016/j.cis.2024.103317. Epub 2024 Oct 21.
Polymer composite microspheres offer several advantages including highly designable structural properties, adjustable micro-nano particle size distribution, easy surface modification, large specific surface area, and high stability. These features make them valuable in various fields such as medicine, sensing, optics, and display technologies, with significant applications in clinical diagnostics, pathological imaging, and drug delivery in the medical field. Currently, microspheres are primarily used in biomedical research as long-acting controlled-release agents and targeted delivery systems, and are widely applied in bone tissue repair, cancer treatment, and wound healing. Different types of polymer microspheres offer distinct advantages and application prospects. Efforts are ongoing to transition successful experimental research to industrial production by expanding various fabrication technologies. This article provides an overview of materials used in microsphere manufacturing, different fabrication methods, modification techniques to enhance their properties and applications, and discusses the role of microspheres in drug delivery engineering.
聚合物复合微球具有许多优点，包括高度可设计的结构特性、可调节的微纳米粒径分布、易于表面改性、大比表面积和高稳定性。这些特性使它们在医学、传感、光学和显示技术等各个领域具有重要的应用价值，在医学领域的临床诊断、病理成像和药物输送方面有显著的应用。目前，微球主要用作生物医学研究中的长效控释剂和靶向输送系统，并广泛应用于骨组织修复、癌症治疗和伤口愈合。不同类型的聚合物微球具有不同的优势和应用前景。目前正在努力通过扩展各种制造技术将成功的实验研究转化为工业生产。本文概述了微球制造中使用的材料、不同的制造方法、用于增强其性能和应用的改性技术，并讨论了微球在药物输送工程中的作用。
