Department of Pharmacy, TPCT's College of Engineering, Osmanabad, Maharashtra, India.
Institute of Pharmaceutical Research, GLA UNIVERSITY, Mathura, UP 281406, India.
Pathol Res Pract. 2024 Nov;263:155659. doi: 10.1016/j.prp.2024.155659. Epub 2024 Oct 15.
Non-coding RNAs (ncRNAs) have become important modulators of gene expression and biological processes, contributing significantly to the initiation and spread of cancer. This study focuses on the complex interactions between ncRNAs and two major signaling pathways-Wnt/β-catenin signaling and cyclin-dependent kinase (CDK)-linked to cancer. We provide an overview of current research on the modulation of these pathways in many cancer types by distinct classes of ncRNAs, such as miRNAs, lncRNAs, and circRNAs. The review focuses on the processes by which ncRNAs regulate cancer cell survival, proliferation, and metastasis. These mechanical processes include CDK activity, the activation of the Wnt/β-catenin cascade and cell cycle advancement. We also discuss the importance of ncRNAs in drug resistance and treatment outcomes, as well as prognosis markers (diagnostic) and therapeutic targets for cancer. Understanding these complex regulatory networks may help in a large way to improve cancer research and diagnosis - but also perhaps treat patients more effectively.
非编码 RNA（ncRNAs）已成为基因表达和生物过程的重要调节剂，对癌症的发生和扩散有重要贡献。本研究关注 ncRNA 与两条主要信号通路——Wnt/β-catenin 信号通路和细胞周期蛋白依赖性激酶（CDK）之间的复杂相互作用，这些信号通路与癌症有关。我们概述了不同种类的 ncRNAs（如 miRNA、lncRNA 和 circRNA）在多种癌症类型中对这些通路的调节作用。本综述重点介绍了 ncRNAs 调节癌细胞存活、增殖和转移的机制。这些机械过程包括 CDK 活性、Wnt/β-catenin 级联的激活和细胞周期的推进。我们还讨论了 ncRNAs 在耐药性和治疗结果、预后标志物（诊断）和癌症治疗靶点方面的重要性。理解这些复杂的调控网络可能会极大地促进癌症研究和诊断——也可能会更有效地治疗患者。
