The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang Province, China.
Medicine (Baltimore). 2024 Oct 11;103(41):e40011. doi: 10.1097/MD.0000000000040011.
Previous studies have shown a significant association between the triglyceride glucose index (TyG) and suicidal ideation in Korean women. However, this association has not yet been examined among American adults. This study aims to investigate the association between TyG and suicidal ideation using data from the National Health and Nutrition Examination Survey. The National Health and Nutrition Examination Survey database from 2005 to 2018 was used, including samples ≥20 years old. Suicidal ideation was assessed through questionnaires, and the TyG was derived from fasting triglyceride and glucose measurements. Weighted logistic regression models were used to analyze the relationship between the TyG and suicidal ideation. Generalized additive model curves explored the nonlinear relationship, while stratified and sensitivity analyses assessed potential interactions and the robustness of the findings. A significance level of P < .05 was considered statistically significant. A total of 15,694 participants were enrolled, of whom 3.67% participants showed suicidal ideation. The mean TyG index for participants with or without suicidal ideation was 8.82 ± 0.76, 8.65 ± 0.68, respectively (P < .001). Multivariable logistic regression showed that a higher level of TyG were associated with a higher likelihood of suicidal ideation (OR = 1.20; 95% CI, 1.05-1.38) after full adjustment. Subgroup analysis and interaction tests showed no significant correlation between gender, age, race, marital status, education, body mass index, poverty income ratio, smoking status, drinking status, diabetes, hypertension, stroke, and cancer (P > .05 for all interactions). Our findings confirm a significant and positive association between the TyG and suicidal ideation among American adults. Further large-scale prospective studies are needed to analyze the role of TyG in suicidal ideation.
先前的研究表明，甘油三酯-血糖指数（TyG）与韩国女性的自杀意念之间存在显著关联。然而，这一关联尚未在美国成年人中进行研究。本研究旨在使用来自全国健康与营养调查的数据，调查 TyG 与自杀意念之间的关联。使用了 2005 年至 2018 年的全国健康与营养调查数据库，纳入年龄≥20 岁的样本。通过问卷评估自杀意念，TyG 由空腹甘油三酯和葡萄糖测量值得出。使用加权逻辑回归模型分析 TyG 与自杀意念之间的关系。广义加性模型曲线探索了非线性关系，而分层和敏感性分析则评估了潜在的交互作用和研究结果的稳健性。具有统计学意义的 P 值<0.05。共纳入 15694 名参与者，其中 3.67%的参与者存在自杀意念。有或没有自杀意念的参与者的 TyG 指数平均值分别为 8.82±0.76、8.65±0.68（P<0.001）。多变量逻辑回归显示，TyG 水平较高与自杀意念的可能性较高相关（OR=1.20；95%CI，1.05-1.38），在充分调整后。亚组分析和交互检验显示，性别、年龄、种族、婚姻状况、教育程度、体重指数、贫困收入比、吸烟状况、饮酒状况、糖尿病、高血压、中风和癌症等因素与 TyG 之间没有显著相关性（所有交互作用的 P 值均>0.05）。我们的研究结果证实了 TyG 与美国成年人自杀意念之间存在显著且正向的关联。需要进一步的大规模前瞻性研究来分析 TyG 在自杀意念中的作用。
