Department of Family Medicine, Korea University Guro Hospital, Seoul, South Korea.
Department of Medicine, Gachon University College of Medicine, Incheon, South Korea.
J Affect Disord. 2024 Jan 1;344:100-103. doi: 10.1016/j.jad.2023.10.082. Epub 2023 Oct 12.
This study investigated the relationship between insulin resistance and suicidal ideation.
We analyzed the data of 21,350 participants from 4 years of the Korea National Health and Nutrition Examination Survey. The triglyceride-glucose (TyG) index was used to assess insulin resistance, and suicidal ideation was recorded through self-reported questionnaires. We used multivariable logistic regression analysis to ensure the independent association between the TyG index and suicidal ideation.
Approximately 4.3 % of participants had suicidal ideation. The TyG index was significantly associated with suicidal ideation, but only among women. Subgroup analysis in women revealed that the association between the TyG index and suicidal ideation was more remarkable in the low-risk group for suicide.
Causality and the impact of unmeasured confounders were not addressed.
The TyG index may help prevent suicide in women via earlier detection of suicidal ideation.
本研究旨在探讨胰岛素抵抗与自杀意念之间的关系。
我们分析了韩国国家健康和营养检查调查 4 年期间的 21350 名参与者的数据。使用三酰甘油-葡萄糖（TyG）指数评估胰岛素抵抗，通过自我报告问卷记录自杀意念。我们使用多变量逻辑回归分析来确保 TyG 指数与自杀意念之间的独立关联。
约有 4.3%的参与者有自杀意念。TyG 指数与自杀意念显著相关，但仅在女性中。女性亚组分析显示，TyG 指数与自杀意念之间的关联在自杀风险较低的人群中更为显著。
未解决因果关系和未测量混杂因素的影响。
TyG 指数可能通过更早地发现自杀意念，帮助预防女性自杀。
