Department of Urology, Jieyang People's Hospital, Jieyang, Guangdong, P. R. China.
Medicine (Baltimore). 2024 Oct 25;103(43):e40289. doi: 10.1097/MD.0000000000040289.
Bladder cancer (BC) is a significant global health issue with high incidence and mortality rates. MicroRNAs (miRNAs) play a crucial role in regulating gene expression and have been found to be dysregulated in BC. Understanding the role of miRNAs in BC development could lead to targeted therapies and improved patient management. Our study presents a thorough examination of the correlation between BC and miRNA research from 2008 to 2022. With the help of 3 powerful methods, including VOSviewer, Biblioshiny, and CiteSpace software, we analyzed the retrieved documents from "Core Collection databases online" on the Web of Science. In total, 798 articles were extracted from the Web of Science, and the number of published papers showed an upward trend from 2008 to 2019. The total number of citations was 21,233, of which the highest paper was a review article written by Chan Jiajia et al in 2018 with 752 citations. Based on the result of the coauthor analysis, Seki Naohiko was the most productive writer and China had the highest volume of published articles. Co-citation analysis was used to reveal the knowledge structure of the research field. In addition to the keywords "Bladder cancer" and "miRNA," "Proliferation," "Biomarkers," and "Apoptosis" were the high-frequency used keywords. Recently, increasingly researchers have paid more attention to the field about BC and miRNA around the worldwide. Through in-depth communication and close collaboration, the veil of miRNA in BC has gradually been unveiled. Bibliometric analysis helps to identify hotspots in research and areas for future investigation.
膀胱癌（BC）是一个具有高发病率和死亡率的重大全球健康问题。MicroRNAs（miRNAs）在调节基因表达中起着关键作用，并且已经发现它们在 BC 中失调。了解 miRNAs 在 BC 发展中的作用可能会导致靶向治疗和改善患者管理。我们的研究对 2008 年至 2022 年期间 BC 和 miRNA 研究之间的相关性进行了全面检查。借助 VOSviewer、Biblioshiny 和 CiteSpace 软件这 3 种强大的方法，我们分析了从 Web of Science 的“Core Collection databases online”中检索到的文献。总共从 Web of Science 中提取了 798 篇文章，发表论文的数量从 2008 年到 2019 年呈上升趋势。总引文数为 21,233，其中最高的一篇论文是 Chan Jiajia 等人于 2018 年撰写的综述文章，被引 752 次。根据合著者分析的结果，Seki Naohiko 是最有成果的作者，中国发表的文章数量最多。共被引分析用于揭示研究领域的知识结构。除了“膀胱癌”和“miRNA”这两个关键词外，“增殖”、“生物标志物”和“凋亡”是高频使用的关键词。最近，全世界越来越多的研究人员开始关注 BC 和 miRNA 领域。通过深入的交流与紧密的合作，miRNA 在 BC 中的面纱逐渐被揭开。文献计量分析有助于确定研究热点和未来研究领域。
