Lu Minhui, Cao Xinyue, Luo Zhiqiang, Bian Feika, Wang Yu, Zhao Yuanjin
Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China.
Small. 2025 Jan;21(1):e2404636. doi: 10.1002/smll.202404636. Epub 2024 Oct 30.
Bacterial infected wounds bring an economic burden to the worldwide medical care field. A variety of bioactives-integrated hydrogel patches are developed in response to this challenge. Here, the melanin hydrogel inverse opal microneedle patches (MNs) with antioxidant and visual color sensing abilities for the management of bacterial infected wounds are proposed. The MNs are fabricated by applying melanin-loaded polyethylene glycol diacrylate (PEGDA) as the inverse opal hydrogel and using bacitracin-carried gelatin to fill those nanopores of hydrogel scaffold. Benefitting from the antioxidant capacity of melanin nanoparticles and the local antimicrobial ability of bacitracin, the resulting MNs possess the integrated functions of reactive oxygen species scavenging and antibacterial. Besides, the inverse opal structure endows the MNs with vivid structure color and detectable reflected wavelength, which can gradually shift with the release of the drug, thus allowing MNs to assess the drug delivery. Based on these characteristics, MNs perform excellent in in vitro drug delivery and monitoring, as well as the promotion of bacterial infected wound recovery in vivo, indicating the potential of MNs in the future wound management field.
细菌感染伤口给全球医疗领域带来了经济负担。针对这一挑战，人们开发了多种集成生物活性物质的水凝胶贴片。在此，我们提出了具有抗氧化和视觉颜色传感能力的黑色素水凝胶反蛋白石微针贴片（MNs），用于治疗细菌感染伤口。通过将负载黑色素的聚乙二醇二丙烯酸酯（PEGDA）用作反蛋白石水凝胶，并使用携带杆菌肽的明胶填充水凝胶支架的纳米孔来制备MNs。得益于黑色素纳米颗粒的抗氧化能力和杆菌肽的局部抗菌能力，所得的MNs具有清除活性氧和抗菌的综合功能。此外，反蛋白石结构赋予MNs鲜艳的结构颜色和可检测的反射波长，并可随药物释放而逐渐变化，从而使MNs能够评估药物递送情况。基于这些特性，MNs在体外药物递送和监测以及促进体内细菌感染伤口愈合方面表现出色，表明MNs在未来伤口管理领域具有潜力。
