[Comparative analysis of the pharmacokinetics of N1-unsubstituted derivatives of 1,4-benzodiazepine].

Parameters of 14C-7-bromo-5-phenyl-1,2-dihydro-3H-1,4-benzodiazepine-2 and its main metabolite distribution in the blood plasma and brain of mice were compared with phenazepam and nordiazepam distribution. Constant ratio of blood plasma 14C-7-bromo-5-phenyl-1,2-dihydro-3A-1,4-benzodiazepine-2, its 3-hydroxy metabolite and other derivatives' level to brain level was noted vs their changing content in the mentioned test objects. Characteristic peculiarities of the distribution of initial 1,4-benzodiazepines and their metabolites and its predictive value are discussed.