Department of Zoology, Faculty of Science, Port Said University, Port Said, 42526, Egypt.
College of Science, Department of Biological Sciences, University of Jeddah, 21589, Jeddah, Saudi Arabia.
Sci Rep. 2024 Oct 30;14(1):26067. doi: 10.1038/s41598-024-74410-8.
Recently, nano-manufactured materials have been used to treat many diseases, such as healing wounds and other modern biological applications. This study investigates the positive effect of Punica granatum seeds extract on kidney and testicular toxicities induced by iron oxide nanoparticles. Forty mice were randomly divided into four groups; the 1st group was the control group. The 2nd group was dosed daily with PSE at 100 g per kg. The 3rd group was dosed with 10 doses of iron oxide nanoparticles at 30 mg/kg b.wt of a mouse per day, 10 times only, then this toxic substance was withdrawn for the rest of the experimental period (30 days). The 4th group was dosed with the same doses as the second and third groups. In this research, we focused on the possibility of using the positive curative effects of PSE, which were estimated at the level of blood chemistry biomarkers, as well as histological and histochemical examinations for the kidney and testis after exposure of mice to iron oxide nanoparticles. These aim to clarify the effect of iron oxide nanoparticles on kidney and testicular morphology and their functions, as well as the potential ameliorative effects of PSE.
最近，纳米制造材料已被用于治疗许多疾病，如伤口愈合和其他现代生物应用。本研究调查了石榴籽提取物对氧化铁纳米颗粒引起的肾和睾丸毒性的积极影响。将 40 只小鼠随机分为四组；第 1 组为对照组。第 2 组每天用 PSE 以 100g/kg 的剂量给药。第 3 组每天给 10 次 30mg/kg bw 的氧化铁纳米粒子，共 10 次，然后在实验期间的其余时间（30 天）撤出这种有毒物质。第 4 组以第二组和第三组相同的剂量给药。在这项研究中，我们专注于使用 PSE 的积极治疗效果的可能性，这是通过血液化学生物标志物的水平来估计的，以及对暴露于氧化铁纳米颗粒的小鼠的肾脏和睾丸进行组织学和组织化学检查。这些旨在阐明氧化铁纳米颗粒对肾脏和睾丸形态及其功能的影响，以及 PSE 的潜在改善作用。
