• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

没食子儿茶素没食子酸酯通过抑制群体感应调节细菌毒力保护小鼠免受血清型鼠伤寒沙门氏菌感染。

Epigallocatechin gallate protects mice from ser. Typhimurium infection by modulating bacterial virulence through quorum sensing inhibition.

机构信息

Animal Experiment Center, Sichuan Academy of Chinese Medicine Sciences, Chengdu, China.

College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.

出版信息

Front Cell Infect Microbiol. 2024 Oct 16;14:1432111. doi: 10.3389/fcimb.2024.1432111. eCollection 2024.

DOI:10.3389/fcimb.2024.1432111
PMID:39479281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11521958/
Abstract

ser. Typhimurium is a common pathogen that poses a considerable public health threat, contributing to severe gastrointestinal diseases and widespread foodborne illnesses. The virulence of Typhimurium is regulated by quorum sensing (QS) and the type III secretion system (T3SS). This study investigated the inhibitory effects and anti-QS activity of epigallocatechin gallate (EGCG), which is a bioactive ingredient found in green tea, on the virulence of Typhimurium. bacterial experiments demonstrated that EGCG inhibited the production of autoinducers, biofilm formation, and flagellar activity by downregulating the expression of AI-1, AI-2, pathogenicity islands (SPI)-1, SPI-2, and genes related to flagella, fimbriae, and curli fibers. In a mouse model of Typhimurium-induced enteritis, EGCG considerably reduced intestinal colonization by . Typhimurium and alleviated intestinal damage. In conclusion, EGCG protects the intestines of mice infected with Typhimurium by inhibiting QS-induced virulence gene expression, demonstrating its potential as a therapeutic agent for controlling Typhimurium infections.

摘要

鼠伤寒沙门氏菌是一种常见的病原体，对公共健康构成相当大的威胁，可导致严重的胃肠道疾病和广泛的食源性疾病。鼠伤寒沙门氏菌的毒力受群体感应（QS）和 III 型分泌系统（T3SS）的调节。本研究探讨了表没食子儿茶素没食子酸酯（EGCG）的抑制作用和抗 QS 活性，EGCG 是绿茶中的一种生物活性成分，对鼠伤寒沙门氏菌的毒力有抑制作用。细菌实验表明，EGCG 通过下调 AI-1、AI-2、致病性岛（SPI）-1、SPI-2 和与鞭毛、菌毛和卷曲纤维相关的基因的表达，抑制了自动诱导物的产生、生物膜形成和鞭毛活性。在鼠伤寒沙门氏菌诱导的肠炎小鼠模型中，EGCG 显著减少了鼠伤寒沙门氏菌在肠道中的定植，并减轻了肠道损伤。总之，EGCG 通过抑制 QS 诱导的毒力基因表达来保护感染鼠伤寒沙门氏菌的小鼠肠道，表明其作为控制鼠伤寒沙门氏菌感染的治疗剂的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa6/11521958/b3f6ab8e71af/fcimb-14-1432111-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa6/11521958/4ecc2a701656/fcimb-14-1432111-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa6/11521958/f9c21247a2d8/fcimb-14-1432111-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa6/11521958/449e69b45b02/fcimb-14-1432111-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa6/11521958/d61d6c04ebfd/fcimb-14-1432111-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa6/11521958/4c30fe711a01/fcimb-14-1432111-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa6/11521958/ef953545363c/fcimb-14-1432111-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa6/11521958/b3f6ab8e71af/fcimb-14-1432111-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa6/11521958/4ecc2a701656/fcimb-14-1432111-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa6/11521958/f9c21247a2d8/fcimb-14-1432111-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa6/11521958/449e69b45b02/fcimb-14-1432111-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa6/11521958/d61d6c04ebfd/fcimb-14-1432111-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa6/11521958/4c30fe711a01/fcimb-14-1432111-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa6/11521958/ef953545363c/fcimb-14-1432111-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa6/11521958/b3f6ab8e71af/fcimb-14-1432111-g007.jpg

相似文献

1
Epigallocatechin gallate protects mice from ser. Typhimurium infection by modulating bacterial virulence through quorum sensing inhibition.没食子儿茶素没食子酸酯通过抑制群体感应调节细菌毒力保护小鼠免受血清型鼠伤寒沙门氏菌感染。
Front Cell Infect Microbiol. 2024 Oct 16;14:1432111. doi: 10.3389/fcimb.2024.1432111. eCollection 2024.
2
Non-pathogenic Heyndrickxia coagulans (Bacillus coagulans) 29-2E inhibits the virulence of pathogenic Salmonella Typhimurium by quorum-sensing regulation.非致病性海氏肠球菌（凝结芽孢杆菌）29-2E 通过群体感应调节抑制致病性鼠伤寒沙门氏菌的毒力。
J Biosci Bioeng. 2024 Jun;137(6):445-452. doi: 10.1016/j.jbiosc.2024.03.002. Epub 2024 Mar 28.
3
LsrR-mediated quorum sensing controls invasiveness of Salmonella typhimurium by regulating SPI-1 and flagella genes.Lsrr 介导的群体感应通过调控 SPI-1 和鞭毛基因控制鼠伤寒沙门氏菌的侵袭性。
PLoS One. 2012;7(5):e37059. doi: 10.1371/journal.pone.0037059. Epub 2012 May 18.
4
Salmonella enterica Serovar Typhimurium SPI-1 and SPI-2 Shape the Global Transcriptional Landscape in a Human Intestinal Organoid Model System.肠炎沙门氏菌血清型 Typhimurium SPI-1 和 SPI-2 在人类肠道类器官模型系统中塑造全球转录景观。
mBio. 2021 May 18;12(3):e00399-21. doi: 10.1128/mBio.00399-21.
5
EGCG-Mediated Potential Inhibition of Biofilm Development and Quorum Sensing in .EGCG 介导的潜在抑制生物膜发育和群体感应。
Int J Mol Sci. 2021 May 6;22(9):4946. doi: 10.3390/ijms22094946.
6
Cinnamaldehyde inhibits type three secretion system in Salmonella enterica serovar Typhimurium by affecting the expression of key effector proteins.肉桂醛通过影响关键效应蛋白的表达抑制鼠伤寒沙门氏菌血清型三型分泌系统。
Vet Microbiol. 2019 Dec;239:108463. doi: 10.1016/j.vetmic.2019.108463. Epub 2019 Oct 21.
7
Role in virulence and protective efficacy in pigs of Salmonella enterica serovar Typhimurium secreted components identified by signature-tagged mutagenesis.通过签名标签诱变鉴定的鼠伤寒沙门氏菌分泌成分在猪的毒力和保护效力中的作用。
Microbiology (Reading). 2007 Jun;153(Pt 6):1940-1952. doi: 10.1099/mic.0.2006/006726-0.
8
Identification of host-specific colonization factors of Salmonella enterica serovar Typhimurium.肠炎沙门氏菌鼠伤寒血清型宿主特异性定植因子的鉴定
Mol Microbiol. 2004 Nov;54(4):994-1010. doi: 10.1111/j.1365-2958.2004.04323.x.
9
Cytosporone B, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium.细胞松素 B，一种沙门氏菌血清型鼠伤寒 Typhimurium Ⅲ型分泌系统的抑制剂。
Antimicrob Agents Chemother. 2013 May;57(5):2191-8. doi: 10.1128/AAC.02421-12. Epub 2013 Mar 4.
10
Harmine, an inhibitor of the type III secretion system of serovar Typhimurium.哈尔明，沙门氏菌血清型 Typhimurium III 型分泌系统的抑制剂。
Front Cell Infect Microbiol. 2022 Sep 13;12:967149. doi: 10.3389/fcimb.2022.967149. eCollection 2022.

引用本文的文献

1
Natural product-based inhibitors of quorum sensing: A novel approach to combat antibiotic resistance.基于天然产物的群体感应抑制剂：对抗抗生素耐药性的新方法。
Biochem Biophys Rep. 2025 Jun 24;43:102111. doi: 10.1016/j.bbrep.2025.102111. eCollection 2025 Sep.

本文引用的文献

1
Quercetin: a promising virulence inhibitor of Pseudomonas aeruginosa LasB in vitro.槲皮素：体外抑制铜绿假单胞菌 LasB 毒力的一种有前景的抑制剂。
Appl Microbiol Biotechnol. 2024 Dec;108(1):57. doi: 10.1007/s00253-023-12890-w. Epub 2024 Jan 5.
2
Tigecycline-resistance mechanisms and biological characteristics of drug-resistant Salmonella Typhimurium strains in vitro.体外耐替加环素鼠伤寒沙门氏菌耐药机制及生物学特性。
Vet Microbiol. 2024 Jan;288:109927. doi: 10.1016/j.vetmic.2023.109927. Epub 2023 Nov 22.
3
Differential regulatory control of curli (csg) gene expression in Salmonella enterica serovar Typhi requires more than a functional CsgD regulator.
鼠李糖脂（csg）基因在伤寒沙门氏菌血清型中的差异调控需要一个功能正常的 CsgD 调节剂。
Sci Rep. 2023 Sep 9;13(1):14905. doi: 10.1038/s41598-023-42027-y.
4
Inhibition of the Type III Secretion System of Salmonella enterica Serovar Typhimurium via Treatment with Fraxetin.通过处理水飞蓟素抑制鼠伤寒沙门氏菌血清型 III 型分泌系统。
Microbiol Spectr. 2022 Dec 21;10(6):e0294922. doi: 10.1128/spectrum.02949-22. Epub 2022 Nov 15.
5
Tea tree oil nanoliposomes: optimization, characterization, and antibacterial activity against Escherichia coli in vitro and in vivo.茶树油纳米脂质体的优化、表征及其对大肠杆菌的体外和体内抗菌活性。
Poult Sci. 2023 Jan;102(1):102238. doi: 10.1016/j.psj.2022.102238. Epub 2022 Oct 10.
6
Controlling of Bacterial Virulence: Evaluation of Anti-Virulence Activities of Prazosin against .细菌毒力的控制：哌唑嗪抗毒力活性对……的评估
Antibiotics (Basel). 2022 Nov 9;11(11):1585. doi: 10.3390/antibiotics11111585.
7
Terazosin Interferes with Quorum Sensing and Type Three Secretion System and Diminishes the Bacterial Espionage to Mitigate the Typhimurium Pathogenesis.特拉唑嗪干扰群体感应和三型分泌系统，并减少细菌的“间谍活动”以减轻鼠伤寒的发病机制。
Antibiotics (Basel). 2022 Mar 30;11(4):465. doi: 10.3390/antibiotics11040465.
8
Impact of Quercetin against Typhimurium Biofilm Formation on Food-Contact Surfaces and Molecular Mechanism Pattern.槲皮素对鼠伤寒沙门氏菌在食品接触表面形成生物膜的影响及分子机制模式
Foods. 2022 Mar 28;11(7):977. doi: 10.3390/foods11070977.
9
Role of Efflux Pump-Mediated Antibiotic Resistance in Quorum Sensing-Regulated Biofilm Formation by Typhimurium.外排泵介导的抗生素耐药性在鼠伤寒沙门氏菌群体感应调节的生物膜形成中的作用
Pathogens. 2022 Jan 24;11(2):147. doi: 10.3390/pathogens11020147.
10
AraC-type regulators HilC and RtsA are directly controlled by an intestinal fatty acid to regulate Salmonella invasion.AraC 型调控因子 HilC 和 RtsA 直接受肠道脂肪酸的控制，从而调节沙门氏菌的侵袭。
Mol Microbiol. 2021 Dec;116(6):1464-1475. doi: 10.1111/mmi.14835. Epub 2021 Nov 8.