Liu Xiangliang, Li Yuguang, Wang Hongyi, Wang Yao, Song Wei, Jia Lin, Li Wei, Cui Jiuwei
Cancer Center, The First Hospital of Jilin University, Changchun, 130021, China.
Department of Stomatology, The First Hospital of Jilin University, Changchun, 130021, China.
Sci Rep. 2024 Dec 28;14(1):31014. doi: 10.1038/s41598-024-82195-z.
Periodontitis is closely related to lifestyle habits. Our objective was to examine the relationship between the Life's Essential 8 (LE8) and the prevalence of periodontitis in American adults. This study used data from the 2009-2014 National Health and Nutrition Examination Survey (NHANES). LE8 scores (range 0-100) were measured according to the definition by the American Heart Association (AHA) and were categorized as low (0-49), medium (50-79), and high (80-100). The NHANES database on periodontal health was used to data to determine the prevalence of periodontitis. Multivariate regression models and restricted cubic spline (RCS) models were used to assess correlations. Weighted quantile sum (WQS) regression was used to explore the association of LE8 and its components with periodontitis risk. Stratified analysis and interaction analysis were conducted to assess the consistency of the results. In addition, mediation analyses were performed to investigate the role of systemic inflammation in mediating the association of LE8 with periodontitis risk. Participants with moderate (LE8 score 50-79) and high (LE8 score 80-100) scores had 58% (95% CI 0.43-0.79, P < 0.001) and 55% (95% CI 0.37-0.84, P = 0.010) less periodontitis prevalence, respectively, compared with adults with lower total scores. Among all 8 indicators, nicotine exposure (62.3%), blood glucose (18.2%), sleep heath (8.2%), and blood pressure (7.7%) had the most significant impact on periodontitis. Notably, no statistically significant interactions were observed in all subgroup analyses except age (P for interaction < 0.05), indicating that the protective effect of LE8 on periodontitis was shown to be more pronounced in individuals between 40 and 60 years of age. In addition, neutrophil, white blood cell (WBC), and albumin levels mediated the association between LE8 and periodontitis risk, mediating proportions of 13.3%, 21.4%, and 8.3%, respectively. These findings suggest that poorer LE8 scores increase the risk of periodontitis, which may be partly mediated by systemic inflammation.
牙周炎与生活习惯密切相关。我们的目标是研究生命必需的八项指标（LE8）与美国成年人牙周炎患病率之间的关系。本研究使用了2009 - 2014年国家健康与营养检查调查（NHANES）的数据。根据美国心脏协会（AHA）的定义测量LE8评分（范围0 - 100），并分为低（0 - 49）、中（50 - 79）和高（80 - 100）三个类别。使用NHANES关于牙周健康的数据库来确定牙周炎的患病率。采用多变量回归模型和受限立方样条（RCS）模型来评估相关性。使用加权分位数和（WQS）回归来探索LE8及其组成部分与牙周炎风险的关联。进行分层分析和交互分析以评估结果的一致性。此外，进行中介分析以研究全身炎症在介导LE8与牙周炎风险关联中的作用。与总分较低的成年人相比，LE8评分为中等（50 - 79）和高（80 - 100）的参与者患牙周炎的患病率分别降低了58%（95%CI 0.43 - 0.79，P < 0.001）和55%（95%CI 0.37 - 0.84，P = 0.010）。在所有八项指标中，尼古丁暴露（62.3%）、血糖（18.2%）、睡眠健康（8.2%）和血压（7.7%）对牙周炎的影响最为显著。值得注意的是，除年龄外，在所有亚组分析中均未观察到具有统计学意义的交互作用（交互作用P < 0.05），这表明LE8对牙周炎的保护作用在40至60岁的个体中更为明显。此外，中性粒细胞、白细胞（WBC）和白蛋白水平介导了LE8与牙周炎风险之间的关联，介导比例分别为13.3%、21.4%和8.3%。这些发现表明，较差的LE8评分会增加患牙周炎的风险，这可能部分由全身炎症介导。
