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用于治疗感染伤口的壳聚糖基敷料的纳米制造及评估

Nanofabrication of chitosan-based dressing to treat the infected wounds: and evaluations.

作者信息

Yousefi Maryam, Ghahremanzadeh Ramin, Nejadmoghaddam Mohammad-Reza, Samadi Fatemeh Yazdi, Najafzadeh Somayeh, Fatideh Fereshteh Mohammadi, Mohammadi Zohreh, Minai-Tehrani Arash

机构信息

Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, 1983969412, Iran.

Department of Pharmaceutics & Pharmaceutical Nanotechnology, School of Pharmacy, Iran University of Medical Sciences, Tehran, 1475886973, Iran.

出版信息

Future Sci OA. 2024 May 15;10(1):FSO921. doi: 10.2144/fsoa-2023-0077. eCollection 2024.

DOI:10.2144/fsoa-2023-0077
PMID:38827799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11140651/
Abstract

Here, an innovative kind of antibacterial nanocomposite film is developed by incorporating graphene oxide and zinc oxide into chitosan matrix. Our dressing was fabricated using the solution casting method. Fourier transform infrared spectra and TGA-DTG clearly confirmed the structure of film dressing. Our results showed the tensile strength and elongation at the break of the films were 20.1 ± 0.7 MPa and 36 ± 10%, respectively. Our fabricated film could absorb at least three-times the fluid of its dry weight while being biocompatible, antibacterial, non-irritant and non-allergic. In addition, it accelerated the healing process of infected wounds by regulating epithelium thickness and the number of inflammatory cells, thus it may be useful for direct application to damaged infected wounds.

摘要

在此，通过将氧化石墨烯和氧化锌掺入壳聚糖基质中，开发出了一种创新型抗菌纳米复合膜。我们的敷料采用溶液浇铸法制备。傅里叶变换红外光谱和热重-微商热重曲线清楚地证实了薄膜敷料的结构。我们的结果表明，薄膜的拉伸强度和断裂伸长率分别为20.1±0.7兆帕和36±10%。我们制备的薄膜在具有生物相容性、抗菌、无刺激性和无过敏性的同时，能够吸收至少三倍于其干重的液体。此外，它通过调节上皮厚度和炎症细胞数量加速了感染伤口的愈合过程，因此可能直接应用于受损感染伤口。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b367/11140651/31a28ab9684d/IFSO_A_2341465_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b367/11140651/248bbbc5740e/IFSO_A_2341465_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b367/11140651/b98a76f8cf8e/IFSO_A_2341465_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b367/11140651/61f74cfa0b8b/IFSO_A_2341465_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b367/11140651/63389afeeb6b/IFSO_A_2341465_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b367/11140651/78a690ad04e5/IFSO_A_2341465_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b367/11140651/31a28ab9684d/IFSO_A_2341465_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b367/11140651/248bbbc5740e/IFSO_A_2341465_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b367/11140651/b98a76f8cf8e/IFSO_A_2341465_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b367/11140651/61f74cfa0b8b/IFSO_A_2341465_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b367/11140651/63389afeeb6b/IFSO_A_2341465_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b367/11140651/78a690ad04e5/IFSO_A_2341465_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b367/11140651/31a28ab9684d/IFSO_A_2341465_F0006_C.jpg

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