Aslam Muhammad Rizwan, Perala Alekya, Wishart Annetta V, Hamouda Ranim K, Elsaady Entesar, Khan Safeera
Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus. 2024 Oct 1;16(10):e70642. doi: 10.7759/cureus.70642. eCollection 2024 Oct.
Diabetes mellitus is a chronic metabolic disease characterized by insulin resistance and hyperglycemia. It can cause various complications, which result in significant morbidity and mortality. There are multiple treatment options available to combat this disease; however, despite this, the incidence of type 2 diabetes mellitus is continuously increasing. Some promising results have shown that dysbiosis has a role in the pathogenesis of type 2 diabetes mellitus and fecal microbiota transplantation (FMT) in animals; however, the usage of FMT in humans needs further clarification and review. We explored PubMed, Popline, and Cochrane Library to identify relevant papers. Eight articles were then finalized after screening and applying eligibility criteria. These articles explored the role of the therapeutic efficacy of FMT in insulin resistance and hyperglycemia. The studies showed that the FMT had a positive impact on managing hyperglycemia and insulin resistance, which is evident in the decline of blood glucose and HBA1c levels and the rise of insulin and C-peptides. In addition, FMT also helped to control other risk factors such as hyperlipidemia and blood pressure; however, the impact on weight loss is not convincing. FMT also influenced the levels of some microbiota, which could be involved in controlling hyperglycemia and insulin resistance. Due to limited control trials and study periods and the small sample size of diabetic patients, more research is needed to explore the impact of FMT in controlling type 2 diabetes mellitus.
糖尿病是一种以胰岛素抵抗和高血糖为特征的慢性代谢性疾病。它可引发多种并发症，导致显著的发病率和死亡率。针对这种疾病有多种治疗选择；然而，尽管如此，2型糖尿病的发病率仍在持续上升。一些有前景的研究结果表明，肠道菌群失调在2型糖尿病的发病机制中起作用，并且在动物实验中粪便微生物群移植（FMT）有一定效果；然而，FMT在人类中的应用需要进一步阐明和审查。我们检索了PubMed、Popline和Cochrane图书馆以识别相关论文。经过筛选和应用纳入标准后，最终确定了8篇文章。这些文章探讨了FMT在胰岛素抵抗和高血糖治疗效果中的作用。研究表明，FMT对控制高血糖和胰岛素抵抗有积极影响，这在血糖和糖化血红蛋白水平下降以及胰岛素和C肽水平升高方面很明显。此外，FMT还有助于控制其他风险因素，如高脂血症和血压；然而，对体重减轻的影响并不令人信服。FMT还影响了一些微生物群的水平，这些微生物群可能参与控制高血糖和胰岛素抵抗。由于对照试验和研究周期有限以及糖尿病患者样本量较小，需要更多研究来探索FMT在控制2型糖尿病方面的影响。
