Department of Preventive and Restorative Dentistry, Araçatuba School of Dentistry, São Paulo State University - UNESP, Araçatuba, SP, Brazil; Laboratory for Bone Metabolism and Regeneration, University of Porto, Faculty of Dental Medicine, Porto, Portugal.
Department of Preventive and Restorative Dentistry, Araçatuba School of Dentistry, São Paulo State University - UNESP, Araçatuba, SP, Brazil.
Arch Oral Biol. 2025 Jan;169:106119. doi: 10.1016/j.archoralbio.2024.106119. Epub 2024 Oct 24.
This scoping review (SR) aimed to investigate the impact of quercetin on mineralized dental tissues intended to be used in preventive and restorative dentistry.
This SR was conducted following the PRISMA-ScR statement. A comprehensive search was performed across databases for articles published up to March 2024. Eligible studies included in vitro and in situ studies and evaluating the potential therapeutic effects of quercetin on dental enamel and dentin. Data were extracted, and synthesis of study findings was conducted.
Out of the 2322 records screened, 22 studies were included in the review. Quercetin, in solution or into dental materials increased the bond strength to enamel and dentin. Additionally, quercetin also enhanced the bond strength of enamel after bleaching. Co-administration of quercetin with fluoride prevented erosive wear and inhibited the proteolytic activity in dentin more effectively than either agent alone. Hardness and modulus of elasticity was higher in dentin treated with quercetin compared to placebo. Reduction of nanoleakage at the composite-dentin interface was reduced in the presence of quercetin as a solution or incorporated into dental adhesives.
Quercetin exhibits promising therapeutic effects on mineralized dental tissues, including remineralization and enhancement of bond strength. It shows potential as a multifunctional agent for improving the longevity and effectiveness of dental biomaterials, as well as in preventing erosion and dental caries. However, as these conclusions are largely drawn from lab-based (in vitro) studies, further research, including clinical trials, is needed to fully explore its therapeutic potential and applications in dentistry.
本范围综述（SR）旨在研究槲皮素对用于预防和修复牙科的矿化牙本质组织的影响。
本 SR 遵循 PRISMA-ScR 声明进行。全面检索了截至 2024 年 3 月发表的文章数据库。纳入的研究包括体外和原位研究，并评估了槲皮素对牙釉质和牙本质的潜在治疗效果。提取数据并对研究结果进行综合。
在筛选出的 2322 条记录中，有 22 项研究纳入了综述。槲皮素溶液或添加到牙科材料中可以提高对牙釉质和牙本质的粘结强度。此外，槲皮素还可以增强漂白后牙釉质的粘结强度。与单独使用氟化物相比，槲皮素与氟化物联合使用可以更有效地防止侵蚀性磨损并抑制牙本质中的蛋白水解活性。与安慰剂相比，用槲皮素处理的牙本质硬度和弹性模量更高。作为溶液或添加到牙科黏合剂中，槲皮素可以减少复合树脂-牙本质界面的纳米渗漏。
槲皮素对矿化牙本质组织具有有前途的治疗效果，包括再矿化和增强粘结强度。它作为一种多功能试剂，具有提高牙科生物材料的耐久性和有效性的潜力，同时还具有预防侵蚀和龋齿的潜力。然而，由于这些结论主要是从基于实验室（体外）的研究中得出的，因此需要进一步的研究，包括临床试验，以充分探索其在牙科中的治疗潜力和应用。
