阿霉素在酸性pH条件下与转铁蛋白-铁的结合
Binding of transferrin-iron by adriamycin at acidic pH.
作者信息
Demant E J, Nørskov-Lauritsen N
出版信息
FEBS Lett. 1986 Feb 17;196(2):321-4. doi: 10.1016/0014-5793(86)80271-x.
PMID:3949004
Abstract
It is shown that adriamycin is able to chelate iron released from iron-loaded serum transferrin in the pH range from 6.5-4.1. The kinetics of iron transfer to free adriamycin and to adriamycin covalently attached to the transferrin has been determined. The results show that adriamycin, if introduced into intracellular acidic compartments, could function as acceptor for transferrin-iron.
摘要
结果表明，阿霉素能够在pH值6.5至4.1范围内螯合从铁负载血清转铁蛋白释放的铁。已经测定了铁向游离阿霉素和与转铁蛋白共价连接的阿霉素转移的动力学。结果表明，如果将阿霉素引入细胞内酸性区室，它可以作为转铁蛋白-铁的受体发挥作用。
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