Li Yunyang, Wu Jingwen, Ye Peilin, Cai Yilin, Shao Mingfei, Zhang Tong, Guo Yanchuan, Zeng Sujuan, Pathak Janak L
School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510182, P. R. China.
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
ACS Biomater Sci Eng. 2024 Dec 9;10(12):7372-7385. doi: 10.1021/acsbiomaterials.4c01764. Epub 2024 Nov 4.
Bone tissue engineering (BTE) is a complex biological process involving the repair of bone tissue with proper neuronal network and vasculature as well as bone surrounding soft tissue. Synthetic biomaterials used for BTE should be biocompatible, support bone tissue regeneration, and eventually be degraded in situ and replaced with the newly generated bone tissue. Recently, various forms of bone graft materials such as hydrogel, nanofiber scaffolds, and 3D printed composite scaffolds have been developed for BTE application. Decellularized extracellular matrix (DECM), a kind of natural biological material obtained from specific tissues and organs, has certain advantages over synthetic and exogenous biomaterial-derived bone grafts. Moreover, DECM can be developed from a wide range of biological sources and possesses strong molding abilities, natural 3D structures, and bioactive factors. Although DECM has shown robust osteogenic, proangiogenic, immunomodulatory, and bone defect healing potential, the rapid degradation and limited mechanical properties should be improved for bench-to-bed translation in BTE. This review summarizes the recent advances in DECM-based BTE and discusses emerging strategies of DECM-based BTE.
骨组织工程（BTE）是一个复杂的生物学过程，涉及用适当的神经网络、脉管系统以及骨周围软组织修复骨组织。用于骨组织工程的合成生物材料应具有生物相容性，支持骨组织再生，并最终在原位降解，被新生成的骨组织替代。最近，已经开发出各种形式的骨移植材料，如水凝胶、纳米纤维支架和3D打印复合支架，用于骨组织工程应用。脱细胞细胞外基质（DECM）是一种从特定组织和器官获得的天然生物材料，与合成和外源性生物材料衍生的骨移植材料相比具有一定优势。此外，脱细胞细胞外基质可以从多种生物来源开发，具有强大的成型能力、天然的三维结构和生物活性因子。尽管脱细胞细胞外基质已显示出强大的成骨、促血管生成、免疫调节和骨缺损愈合潜力，但在骨组织工程从实验台到临床应用的转化中，其快速降解和有限的力学性能仍有待改善。本文综述了基于脱细胞细胞外基质的骨组织工程的最新进展，并讨论了基于脱细胞细胞外基质的骨组织工程的新兴策略。
