The application of explainable artificial intelligence (XAI) in electronic health record research: A scoping review.

Machine Learning (ML) and Deep Learning (DL) models show potential in surpassing traditional methods including generalised linear models for healthcare predictions, particularly with large, complex datasets. However, low interpretability hinders practical implementation. To address this, Explainable Artificial Intelligence (XAI) methods are proposed, but a comprehensive evaluation of their effectiveness is currently limited. The aim of this scoping review is to critically appraise the application of XAI methods in ML/DL models using Electronic Health Record (EHR) data. In accordance with PRISMA scoping review guidelines, the study searched PUBMED and OVID/MEDLINE (including EMBASE) for publications related to tabular EHR data that employed ML/DL models with XAI. Out of 3220 identified publications, 76 were included. The selected publications published between February 2017 and June 2023, demonstrated an exponential increase over time. Extreme Gradient Boosting and Random Forest models were the most frequently used ML/DL methods, with 51 and 50 publications, respectively. Among XAI methods, Shapley Additive Explanations (SHAP) was predominant in 63 out of 76 publications, followed by partial dependence plots (PDPs) in 11 publications, and Locally Interpretable Model-Agnostic Explanations (LIME) in 8 publications. Despite the growing adoption of XAI methods, their applications varied widely and lacked critical evaluation. This review identifies the increasing use of XAI in tabular EHR research and highlights a deficiency in the reporting of methods and a lack of critical appraisal of validity and robustness. The study emphasises the need for further evaluation of XAI methods and underscores the importance of cautious implementation and interpretation in healthcare settings.