Yu Yun-Mei, Long Yuan-Zhu, Zhu Zhao-Qiong
Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People's Republic of China.
J Pain Res. 2024 Oct 30;17:3539-3551. doi: 10.2147/JPR.S480926. eCollection 2024.
Local anesthetics, particularly amide types, play a crucial role in perioperative anesthesia to alleviate pain and manage chronic, long-term pain, with their brief effect period remaining a universal challenge that needs resolution. There is a high anticipation for creating materials that maintain prolonged effectiveness of local anesthetics through a straightforward administration technique. Chitosan is the most typical natural amino polymer, which is highly reactive and easy to modify. It has been widely and deeply used in the field of medicine. At present, it is mainly used in tissue regeneration and repair, hemostasis and wound healing, antibacterial and anti-infection, disease diagnosis and treatment detection, and drug delivery. In the field of anesthesia, chitosan is regarded as a potential perfect carrier for the sustained release of amide local anesthetics. This document aims to analyze the current application of chitosan as a prolonged-release substance in amide-type local anesthetics, encapsulate the associated research advancements, and subsequently investigate the practicality and prospects of its medical uses.
局部麻醉药，尤其是酰胺类，在围手术期麻醉中发挥着关键作用，以减轻疼痛并管理慢性长期疼痛，但其作用时间短暂仍是一个需要解决的普遍挑战。人们对通过简单给药技术来制造能维持局部麻醉药长效作用的材料寄予厚望。壳聚糖是最典型的天然氨基聚合物，具有高反应性且易于改性。它已在医学领域得到广泛而深入的应用。目前，它主要用于组织再生与修复、止血与伤口愈合、抗菌与抗感染、疾病诊断与治疗检测以及药物递送。在麻醉领域，壳聚糖被视为酰胺类局部麻醉药缓释的潜在理想载体。本文旨在分析壳聚糖作为酰胺类局部麻醉药长效释放物质的当前应用情况，总结相关研究进展，进而探讨其医学用途的实用性和前景。
