Herdiana Yedi, Husni Patihul, Nurhasanah Siti, Shamsuddin Shaharum, Wathoni Nasrul
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia.
Faculty of Agricultural Industrial Technology, Universitas Padjadjaran, Sumedang 45363, Indonesia.
Polymers (Basel). 2023 Jul 5;15(13):2953. doi: 10.3390/polym15132953.
Breast cancer is a major cause of death globally, accounting for around 13% of all deaths. Chemotherapy, the common treatment for cancer, can have side effects that lead to the production of reactive oxygen species (ROS) and an increase in oxidative stress in the body. Antioxidants are important for maintaining the health of cells and helping the immune system function properly. They play a crucial role in balancing the body's internal environment. Using natural antioxidants is an alternative to mitigate the harmful effects of oxidative stress. However, around 80% of natural antioxidants have limited effectiveness when taken orally because they do not dissolve well in water or other solvents. This poor solubility affects their ability to be absorbed by the body and limits their bioavailability. One strategy that has been considered is to increase their water solubility to increase their oral bioavailability. Chitosan-based nanoparticle (CSNP) systems have been extensively explored due to their reliability and simpler synthesis routes. This review focuses on the various methods of chitosan-based nanoformulation for developing effective oral dosage forms for natural antioxidants based on the pharmacokinetics and pharmacodynamics properties. Chitosan (CS) could be a model, because of its wide use in polymeric NPs research, thus providing a better understanding of the role of vehicles that carry natural antioxidants in maintaining the stability and enhancing the performance of cancer drugs.
乳腺癌是全球主要的死亡原因之一，约占所有死亡人数的13%。化疗作为癌症的常见治疗方法，可能会产生副作用，导致活性氧（ROS）的产生以及体内氧化应激的增加。抗氧化剂对于维持细胞健康和帮助免疫系统正常运作至关重要。它们在平衡身体内部环境方面发挥着关键作用。使用天然抗氧化剂是减轻氧化应激有害影响的一种替代方法。然而，大约80%的天然抗氧化剂口服时效果有限，因为它们在水或其他溶剂中的溶解性不佳。这种低溶解度影响了它们被身体吸收的能力，并限制了它们的生物利用度。一种被考虑的策略是提高它们的水溶性以增加其口服生物利用度。基于壳聚糖的纳米颗粒（CSNP）系统因其可靠性和更简单的合成路线而得到广泛研究。本综述基于药代动力学和药效学特性，重点关注基于壳聚糖的纳米制剂开发天然抗氧化剂有效口服剂型的各种方法。壳聚糖（CS）可以作为一个模型，因为它在聚合物纳米颗粒研究中广泛应用，从而能更好地理解携带天然抗氧化剂的载体在维持癌症药物稳定性和增强其性能方面的作用。
