Department of Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, China.
Lipids Health Dis. 2024 Nov 4;23(1):358. doi: 10.1186/s12944-024-02350-3.
Stress urinary incontinence (SUI), a common disorder of the pelvic floor, often results in anxiety, poor quality of life, and psychological issues among its sufferers. The relationship between lipid accumulation products (LAP) and stress-related urine incontinence remains unclear. This research aimed to investigate any possible correlation between the risk of SUI and the level of lipid accumulation products.
For this cross-sectional research, people with SUI who were 20 years of age or older were recruited using information from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. A weighted multivariate logistic regression model was used to evaluate the findings. As a potential biomarker, lipid accumulation product levels were sorted among individuals in ascending order and subjected to a trend test (P for trend). Additionally, a nonlinear analysis was conducted using smooth curve-fitting methods. Lipid accumulation products' effectiveness in predicting SUI was evaluated using receiver operating characteristic (ROC) curves. Finally, a subgroup analysis was performed to confirm that the connection between SUI and lipid accumulation products was consistent across all demographic groups.
A thorough survey performed on 14,945 participants indicated that 23.61% of the respondents had SUI. A noteworthy association was observed between higher lipid accumulation product values and a greater probability of SUI in multivariate logistic regression analysis. Specifically, the stratification of lipid accumulation products into quartiles demonstrated a substantial positive correlation between the upper and lower quartiles, as evidenced by an elevated odds ratio for SUI (OR = 1.92; 95%CI 1.51-2.44; P < 0.0001). The subgroup analysis supported link consistency across all cohorts under investigation. Finally, the ROC curve indicated that lipid accumulation products (AUC = 0.67, 95%CI 0.654-0.690) had a superior predictive effect on the likelihood of SUI.
Increased lipid accumulation product values are associated with a higher chance of SUI in adult participants. This suggests that lipid accumulation products could be a valuable marker for detecting SUI, offering new perspectives for its evaluation and treatment.
压力性尿失禁（SUI）是一种常见的盆底功能障碍性疾病，常导致患者出现焦虑、生活质量下降和心理问题。脂联素与压力性尿失禁之间的关系尚不清楚。本研究旨在探讨脂联素水平与压力性尿失禁风险之间的可能相关性。
本横断面研究采用 2005 年至 2018 年全国健康与营养调查（NHANES）的信息，招募年龄在 20 岁及以上的 SUI 患者。采用加权多变量 logistic 回归模型评估结果。脂联素水平作为一种潜在的生物标志物，根据个体进行升序排序，并进行趋势检验（趋势检验 P 值）。此外，采用平滑曲线拟合方法进行非线性分析。采用受试者工作特征（ROC）曲线评估脂联素预测 SUI 的效果。最后，进行亚组分析以确认 SUI 与脂联素之间的关联在所有人群中是一致的。
对 14945 名参与者进行的全面调查显示，23.61%的受访者患有 SUI。多变量 logistic 回归分析显示，脂联素水平较高与 SUI 的可能性较大之间存在显著关联。具体而言，将脂联素分为四分位区间表明，上四分位数和下四分位数之间存在显著的正相关关系，SUI 的优势比升高（OR=1.92；95%CI 1.51-2.44；P<0.0001）。亚组分析支持所有研究队列之间的关联一致性。最后，ROC 曲线表明脂联素（AUC=0.67，95%CI 0.654-0.690）对 SUI 发生的可能性具有更好的预测效果。
成人参与者中脂联素水平升高与 SUI 发生的几率增加相关。这表明脂联素可能是检测 SUI 的有价值标志物，为其评估和治疗提供了新视角。
