Sar Bandana, Ahsan Mollah Rohan, Mukherjee Arijit
Department of Chemistry Birla Institute of Science and Technology (BITS) Pilani Hyderabad campus Hyderabad 500078 Telangana India
RSC Adv. 2024 Nov 4;14(47):34843-34847. doi: 10.1039/d4ra05652c. eCollection 2024 Oct 29.
A crystal structure is no longer conceived as a static entity; rather, it often mirrors crystallization pathways, linking crystal structures with a solution scenario. In this study, taking a clue from a previously reported ionic cocrystal structure, an acetic acid-based catalytic protocol is developed for the -acylation of amines using ester sources. In addition to better catalytic efficiency, this approach was extended further to a mechanochemistry protocol in the context of a multicomponent reaction. This points towards a broader applicability of crystal structures that goes beyond the domain of structural chemistry and delves into catalysis and mechanosynthesis.
晶体结构不再被视为一个静态实体；相反，它常常反映结晶途径，将晶体结构与溶液情况联系起来。在本研究中，从先前报道的离子共晶结构中获得线索，开发了一种基于乙酸的催化方案，用于使用酯源对胺进行 - 酰化反应。除了具有更好的催化效率外，该方法还在多组分反应的背景下进一步扩展为机械化学方案。这表明晶体结构具有更广泛的适用性，其范围超出了结构化学领域，深入到催化和机械合成领域。
