Cavedon Elisabetta, Manso Jacopo, Negro Isabella, Censi Simona, Serra Roberto, Busetto Luca, Vettor Roberto, Plebani Mario, Pezzani Raffaele, Nacamulli Davide, Mian Caterina
Familial Cancer Clinic and Oncoendocrinology, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
Endocrinology Unit, Department of Medicine, University of Padua, Padua, Italy.
Int J Endocrinol. 2020 May 28;2020:4802739. doi: 10.1155/2020/4802739. eCollection 2020.
Adequate levels of selenium (Se) have protective effects against several chronic diseases, such as obesity. The aim of this study was to assess the effect of Se supplementation in a selected group of patients with obesity.
This randomized prospective study included 37 overweight/obese individuals aged 18-65 years, who adopted a slightly hypocaloric diet for 3 months. An intervention group received 240 g/day of L-selenomethionine for 3 months; a control group received a placebo. Clinical and biochemical parameters, body composition measurements, and the Psychological General Well-Being Index (PGWBI) questionnaire were tested at the beginning and end of the treatment.
A comparison of the two groups showed a significant change in body composition, involving a decrease in body fat mass, between the baseline and the end of the follow-up, in the intervention group. Unlike the placebo group, the group given Se had a significant increase in lean body and muscle mass and a significant decrease in leptin levels after 3 months on diet. At the end of the follow-up, the group given Se scored higher on the PGWBI than those who did not.
Se could reinforce the effects of diet for overweight and obesity. This work was registered in the ISRCTN registry with study ID ISRCTN6106073.
充足的硒（Se）水平对多种慢性疾病具有保护作用，如肥胖症。本研究旨在评估补充硒对一组特定肥胖患者的影响。
这项随机前瞻性研究纳入了37名年龄在18至65岁之间的超重/肥胖个体，他们采用轻度低热量饮食3个月。干预组连续3个月每天服用240克L-硒代蛋氨酸；对照组服用安慰剂。在治疗开始和结束时测试临床和生化参数、身体成分测量结果以及心理总体幸福感指数（PGWBI）问卷。
两组比较显示，干预组在随访基线至结束期间身体成分有显著变化，包括体脂量减少。与安慰剂组不同，服用硒的组在饮食3个月后瘦体重和肌肉量显著增加，瘦素水平显著降低。随访结束时，服用硒的组在PGWBI上的得分高于未服用者。
硒可增强饮食对超重和肥胖的作用。本研究已在ISRCTN注册中心注册，研究识别号为ISRCTN6106073。
