Liu Shuaiyin, Ning Tianqin, Chen Junlin, Fu Yanzhe, Li Jiebo, Li Jinyu, Niu Xufeng, Fan Yubo
Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China.
Department of Orthopedic, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100007, China.
Innovation (Camb). 2024 Sep 30;5(6):100705. doi: 10.1016/j.xinn.2024.100705. eCollection 2024 Nov 4.
Effective disease management based on real-time physiological changes presents a significant clinical challenge. A flexible electrode system integrating diagnosis and treatment can overcome the uncertainties associated with treatment progress during localized interventions. In this study, we develop a system featuring a biomimetic feedback regulation mechanism for drug delivery and real-time monitoring. To prevent drug leakage, the system incorporates a magnesium (Mg) valve in the outer layer, ensuring zero leakage when drug release is not required. The middle layer contains a drug-laden poly(3,4-ethylenedioxythiophene) (PEDOT) sponge (P-sponge), which supplies the water to partially or fully activate the Mg valve under electrical stimulation and initiate drug release. Once the valve is fully opened, the exposed and expanded P-sponge electrode establishes excellent contact with various tissues, facilitating the collection of electrophysiological signals. Encapsulation with polylactic acid film ensures the system's flexibility and bioresorbability, thereby minimizing potential side effects on surrounding tissues. Animal experiments demonstrate the system's capability to mimic feedback modulation mechanisms, enabling real-time monitoring and timely drug administration. This integrated diagnosis and treatment system offers an effective solution for the emergency management of acute diseases in clinical settings.
基于实时生理变化的有效疾病管理面临重大临床挑战。一种集成诊断与治疗功能的柔性电极系统能够克服局部干预过程中与治疗进展相关的不确定性。在本研究中，我们开发了一种具有仿生反馈调节机制的药物递送与实时监测系统。为防止药物泄漏，该系统在外层包含一个镁（Mg）阀，在不需要药物释放时确保零泄漏。中间层含有载药的聚（3,4 - 亚乙基二氧噻吩）（PEDOT）海绵（P - 海绵），其提供水分以在电刺激下部分或完全激活Mg阀并启动药物释放。一旦阀门完全打开，暴露并膨胀的P - 海绵电极与各种组织建立良好接触，便于采集电生理信号。用聚乳酸膜封装可确保系统的柔韧性和生物可吸收性，从而将对周围组织的潜在副作用降至最低。动物实验证明了该系统模拟反馈调节机制的能力，能够实现实时监测和及时给药。这种集成诊断与治疗系统为临床环境中急性疾病的应急管理提供了一种有效解决方案。
