Endalew Sisay Awoke, Abebaw Belete Tesfaw
Department of Chemistry, College of Natural Science, Wollo University, P.O. Box 1145, Dessie, Ethiopia.
Adv Pharmacol Pharm Sci. 2024 Oct 28;2024:2938314. doi: 10.1155/2024/2938314. eCollection 2024.
This study investigated the anti-inflammatory properties of , an herbal preparation. Qualitative and quantitative phytochemical analyses were conducted to identify active compounds in the preparation. The researchers also assessed its ability to inhibit the production of pro-inflammatory enzymes, cyclooxygenases (COX-1, COX-2), and lipoxygenase (5-LOX) in vitro. The extracts demonstrated dose-dependent inhibition of these enzymes, with some extracts showing IC values comparable to standard anti-inflammatory drugs. The ethanol extract exhibited significant inhibition of 5-LOX (52.99 μg/mL), compared to the standard drug zileuton (32.41 μg/mL), while the inhibition of COX-1 (66.00 μg/mL) and COX-2 (71.62 μg/mL) was comparable to the standard drug indomethacin (40.57 and 54.39 μg/mL, respectively). These findings suggest that has the potential to be used as a herbal remedy for treating inflammatory conditions. By inhibiting pro-inflammatory enzymes, the extracts may effectively reduce inflammation and promote tissue healing or repair. The inhibition potential of extract of this plant can be taken as a good candidate of anti-inflammatory agent.
本研究调查了一种草药制剂的抗炎特性。进行了定性和定量植物化学分析，以确定该制剂中的活性化合物。研究人员还评估了其在体外抑制促炎酶环氧化酶（COX - 1、COX - 2）和脂氧合酶（5 - LOX）产生的能力。提取物对这些酶表现出剂量依赖性抑制，一些提取物的IC值与标准抗炎药物相当。与标准药物齐留通（32.41μg/mL）相比，乙醇提取物对5 - LOX表现出显著抑制（52.99μg/mL），而对COX - 1（66.00μg/mL）和COX - 2（71.62μg/mL）的抑制作用与标准药物吲哚美辛（分别为40.57和54.39μg/mL）相当。这些发现表明，该制剂有潜力用作治疗炎症性疾病的草药疗法。通过抑制促炎酶，提取物可能有效减轻炎症并促进组织愈合或修复。这种植物提取物的抑制潜力可被视为一种良好的抗炎剂候选物。
