Antimalarial activity of the 80%methanol extract and solvent fractions of A. rich roots against in mice.

ETHNOPHARMACOLOGICAL RELEVANCE

Malaria is still a known health threat, especially in parts of sub-Saharan Africa. It is one of the frequently mentioned issues with hospital admission and outpatient care in Ethiopia. A. Rich roots are historically used in Ethiopia to treat meningitis, inflammation, and malaria. However, the antimalarial activity of this plant has not been scientifically studied so far.

AIM OF THE STUDY

This study aimed to determine the antimalarial activity of 80% methanol extract and solvent fractions of the roots of against infection in mice.

METHODS

The i antimalarial activity of the 80% methanol extract and solvent fractions of A. Rich was evaluated by standard chemo suppressive, curative and repository tests using (ANKA strain) in Swiss albino mice at doses of 100, 200 and 400 mg/kg/day. The level of parasitemia, survival time, variation in weight, rectal temperature, and packed cell volume of mice were determined to establish the activity of the extracts.

RESULT

The 80% methanol extract of A. Rich roots had a promising suppression of parasitemia at 400 mg/kg with a chemosuppression value of 65.21 ± 1.20%. Among the solvent fractions, the chloroform fraction showed the highest antimalarial activity in the four-day suppressive test with a chemosuppression value of 55.9 ± 0.28%, followed by the n-butanol (42.9 ± 0.24%), and aqueous (40.57 ± 0.52%) fractions at a dose of 400 mg/kg. The highest survival times were observed with crude extract (15.4 ± 0.24 days) at 400 mg/kg, and chloroform fraction (13.4 + 0.24 days), though all extracts increased survival time.

CONCLUSION

The findings of the present study collectively indicate the root extract of has a promising antiplasmodial activity which substantiates the traditional claim of the plant.