Andrade Mônica Viegas, Noronha Kenya, Guedes Gilvan Ramalho, Diniz Bernardo Campolina, Silva Valéria Andrade, de Souza Aline, de Carvalho Lucas Resende, Braga Paulo Estevão, Motta-Santos André Soares, Julião Nayara Abreu, da Silva Daniel Nogueira, Bracarense Henrique, Castro Marcia C
Centre of Regional Planning and Development (Cedeplar-UFMG), Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Núcleo de Avaliação de Tecnologias em Saúde (NATS) do Hospital das ClínicasUniversidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Qual Life Res. 2025 Feb;34(2):325-339. doi: 10.1007/s11136-024-03822-w. Epub 2024 Nov 6.
This paper aims to conduct a systematic review (SR) to assess Health-Related Quality of Life (HRQoL) of malaria-exposed populations for different regions where malaria is endemic, considering any health measurements.
An electronic search of the Medline, Lilacs, and Embase databases was conducted until February 2nd, 2024, to identify and select studies that evaluated HRQoL. No restrictions on place or language were made.
Thirty-seven studies were included, among them 21 focused on African countries. The most investigated HRQoL outcome associated with malaria was Disability-Adjusted Life Years (DALYs). These studies primarily aim to analyze the epidemiological burden of the disease or to conduct economic assessments. Only four studies conducted field research using specific instruments to assess the HRQoL of individuals experiencing malaria episodes. Three of them estimated EQ-5D utility index and found scores varying from 0.349 for severe malaria (Indonesia) to 0.74 (Nigeria). The health domains that are most affected by malaria are pain and discomfort and usual activities (EQ-5D instrument) and physical domains (WHOQOL-BREF). These results reflect the main malaria symptoms which are fever, headache, and generalized pain.
This SR highlights a significant gap in understanding the quality of life among individuals experiencing malaria. Despite being an acute illness, recurrent episodes of malaria can lead to considerable loss in quality of life. Moreover, there are significant equity implications, as malaria remains endemic in socioeconomically disadvantaged populations.
本文旨在进行一项系统评价（SR），以评估疟疾流行的不同地区接触疟疾人群的健康相关生活质量（HRQoL），考虑任何健康测量指标。
对Medline、Lilacs和Embase数据库进行电子检索，直至2024年2月2日，以识别和选择评估HRQoL的研究。对地点或语言不设限制。
纳入了37项研究，其中21项聚焦于非洲国家。与疟疾相关的最常研究的HRQoL结果是伤残调整生命年（DALYs）。这些研究主要旨在分析该疾病的流行病学负担或进行经济评估。只有四项研究使用特定工具进行实地研究，以评估经历疟疾发作的个体的HRQoL。其中三项估计了EQ-5D效用指数，发现得分从严重疟疾（印度尼西亚）的0.349到尼日利亚的0.74不等。受疟疾影响最大的健康领域是疼痛与不适以及日常活动（EQ-5D工具）和身体领域（WHOQOL-BREF）。这些结果反映了疟疾的主要症状，即发热、头痛和全身疼痛。
本系统评价突出了在了解疟疾患者生活质量方面的重大差距。尽管疟疾是一种急性疾病，但反复发作会导致生活质量大幅下降。此外，由于疟疾在社会经济弱势人群中仍然流行，因此存在重大的公平问题。
