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嗜肺军团菌血清群抗原与脂多糖之间的关系。

The relationship between the serogroup antigen and lipopolysaccharide of Legionella pneumophila.

作者信息

Conlan J W, Ashworth L A

出版信息

J Hyg (Lond). 1986 Feb;96(1):39-48. doi: 10.1017/s0022172400062513.

DOI:10.1017/s0022172400062513
PMID:3950395
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2129596/
Abstract

Serogroup-specific antigen was extracted from a number of Legionella pneumophila strains and compared with phenol-water extracted lipopolysaccharide on the basis of gel filtration, chemical analysis, SDS-PAGE and reaction with serogroup-specific antibody in immunoblots. Serogroup specificity is apparently borne by the O side-chains of the lipopolysaccharide, which, although smooth in type, partitions in the phenol phase. For four serogroup 1 strains tested, there was no qualitative correlation between O side-chain length and pulmonary virulence for guinea-pigs.

摘要

从多个嗜肺军团菌菌株中提取了血清群特异性抗原，并在凝胶过滤、化学分析、SDS - 聚丙烯酰胺凝胶电泳以及免疫印迹中与酚 - 水提取的脂多糖和血清群特异性抗体的反应进行了比较。血清群特异性显然由脂多糖的O侧链所携带，尽管其类型为光滑型，但在酚相中分配。对于所测试的4株血清群1菌株，O侧链长度与豚鼠的肺毒力之间没有定性相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72bd/2129596/3730d8561ec2/jhyg00004-0051-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72bd/2129596/f12856c7cf42/jhyg00004-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72bd/2129596/3730d8561ec2/jhyg00004-0051-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72bd/2129596/f12856c7cf42/jhyg00004-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72bd/2129596/3730d8561ec2/jhyg00004-0051-a.jpg

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本文引用的文献

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Lipid A in Legionella pneumophila.嗜肺军团菌中的脂多糖A
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Virulence factors of the family Legionellaceae.军团菌科的毒力因子。
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J Infect Dis. 1982 Feb;145(2):224-33. doi: 10.1093/infdis/145.2.224.
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Lipopolysaccharide heterogeneity in Salmonella typhimurium analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis.通过十二烷基硫酸钠聚丙烯酰胺凝胶电泳分析鼠伤寒沙门氏菌中的脂多糖异质性。
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Liquid medium for growth of Legionella pneumophila.嗜肺军团菌生长的液体培养基。
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Crossed immunoelectrophoretic analysis of Legionella pneumophila serogroup 1 antigens.嗜肺军团菌血清1型抗原的交叉免疫电泳分析
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