单克隆抗体识别的源自不同嗜肺军团菌血清型1菌株的尿抗原上的共同表位。
Common epitope on urinary antigen derived from different Legionella pneumophila serogroup 1 strains recognized by a monoclonal antibody.
作者信息
Helbig J H, Lück P C, Pilz C, Witzleb W
机构信息
Medical Academy Carl Gustav Carus Dresden, Institute of Medical Microbiology, GDR.
出版信息
Zentralbl Bakteriol. 1990 Sep;273(4):478-80. doi: 10.1016/s0934-8840(11)80455-x.
Guinea pigs were infected intraperitoneally with 4 subgroup reference strains (Knoxville 1, Philadelphia 1, Bellingham 1, OLDA) and 2 clinical isolates of Legionella pneumophila serogroup 1. Antigenuria was demonstrated by the enzyme-linked immunosorbent assay using polyclonal antibodies and monoclonal antibody (mab) F8/5. Mab F8/5 recognizes a hitherto undetected common epitope on urinary antigen of the investigated strains.
将豚鼠经腹腔注射感染4种1型嗜肺军团菌亚组参考菌株（诺克斯维尔1型、费城1型、贝灵汉姆1型、OLDA）和2株临床分离株。采用多克隆抗体和单克隆抗体F8/5，通过酶联免疫吸附测定法检测尿抗原。单克隆抗体F8/5识别所研究菌株尿抗原上一个迄今未被发现的共同表位。
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