Sisli Selen Nihal, Ozasir Birgul, Ozasir Tufan, Yuzer Derin Bugu, Gulsahi Kamran
Department of Endodontics, Faculty of Dentistry, Baskent University, Ankara, Turkey.
Med Princ Pract. 2025;34(3):291-300. doi: 10.1159/000542398. Epub 2024 Nov 6.
This pilot retrospective case-control study questioned whether systemic statin use causes pulp calcification using cone-beam computed tomography (CBCT) images from the patients prescribed oral statins and comparing those of healthy individuals.
CBCT scans of 54 patients, including 27 age- and sex-matched patients for the study and control groups, were analysed using Mimics Innovation Suite software. The study included patients using statins regularly for at least 1 year. Only intact teeth with opposing teeth were selected for the study group and matched with the control group. Dental crown and pulp chamber volumes were calculated and proportioned. The data were analysed with chi-square and Shapiro-Wilk tests to assess normal distribution, followed by Mann-Whitney U test if necessary.
Statistical analysis showed no difference between the study and control groups (p = 0.505). Statin use duration did not cause statistically significant difference in terms of the reduction of pulp chamber volume (p = 0.141).
Within the limitations of the study, systemic statin use did not cause dental pulp calcification. The results suggest, oral administration of the statin drugs is not an unfavourable condition for dental practice. Further studies with larger numbers of patients are needed to support this conclusion.
这项初步回顾性病例对照研究通过对口服他汀类药物患者的锥束计算机断层扫描（CBCT）图像进行分析，并与健康个体的图像进行比较，探讨全身使用他汀类药物是否会导致牙髓钙化。
使用Mimics Innovation Suite软件对54例患者的CBCT扫描图像进行分析，其中包括27例年龄和性别匹配的研究组和对照组患者。该研究纳入了规律使用他汀类药物至少1年的患者。研究组仅选择有对颌牙的完整牙齿，并与对照组进行匹配。计算并比较牙冠和牙髓腔的体积。采用卡方检验和Shapiro-Wilk检验分析数据以评估正态分布，必要时采用Mann-Whitney U检验。
统计分析显示研究组和对照组之间无差异（p = 0.505）。他汀类药物的使用时长在牙髓腔体积减少方面未引起统计学显著差异（p = 0.141）。
在本研究的局限性范围内，全身使用他汀类药物不会导致牙髓钙化。结果表明，口服他汀类药物对牙科实践并非不利条件。需要更多患者参与的进一步研究来支持这一结论。
