Bende M, Löth S
J Laryngol Otol. 1986 Mar;100(3):285-8. doi: 10.1017/s0022215100099151.
Oxymetazoline, a derivative of imidazoline, is a widely used nasal decongestant. In contrast to other topical decongestants related to phenylephrine, sympathomimetic amines, it also induces a reduced nasal mucosal blood flow. The purpose of the present investigation was to evaluate the duration of effect of oxymetazoline on nasal airway resistance and mucosal blood flow. During the eight hours of study, the blood flow was reduced by 30-40 per cent in six hours. A similar decongestant effect of about 30 per cent was found during the same interval. The pharmacological profile of oxymetazoline seems questionable, since a reduced nasal mucosal blood flow might not be of value in the treatment of upper airways infections.
羟甲唑啉是一种咪唑啉衍生物，是一种广泛使用的鼻减充血剂。与其他与去氧肾上腺素、拟交感神经胺相关的局部减充血剂不同，它还会导致鼻黏膜血流减少。本研究的目的是评估羟甲唑啉对鼻气道阻力和黏膜血流的作用持续时间。在研究的八小时内，血流在六小时内减少了30%至40%。在相同时间段内发现了约30%的类似减充血效果。羟甲唑啉的药理学特性似乎值得怀疑，因为鼻黏膜血流减少在治疗上呼吸道感染时可能没有价值。
