van den Nieuwenhof Daan W A, Moroni Lorenzo, Chou Joshua, Hinkelbein Jochen
Department of Otorhinolaryngology, Radboud University Medical Center, Nijmegen, The Netherlands.
MERLN Institute for Technology-Inspired Regenerative Medicine, Department of Complex Tissue Engineering, Maastricht University, Maastricht, The Netherlands.
NPJ Microgravity. 2024 Nov 6;10(1):102. doi: 10.1038/s41526-024-00442-z.
The rising aging population underscores the need for advances in tissue engineering and regenerative medicine. Alterations in cellular response in microgravity might be pivotal in unraveling the intricate cellular mechanisms governing tissue and organ regeneration. Microgravity could improve multicellular spheroid, tissue, and organ formation. This review summarizes microgravity-induced cellular alterations and highlights the potential of tissue engineering in microgravity for future breakthroughs in space travel, transplantation, drug testing, and personalized medicine.
老龄化人口的增加凸显了组织工程和再生医学取得进展的必要性。微重力环境下细胞反应的改变可能在揭示组织和器官再生复杂细胞机制方面起着关键作用。微重力能够促进多细胞球体、组织和器官的形成。本综述总结了微重力诱导的细胞变化，并强调了微重力环境下组织工程在太空旅行、移植、药物测试和个性化医疗未来突破方面的潜力。
