Reproductive and Genetic Center of National Research Institute for Family Planning, Beijing, 100081, China.
Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100080, China.
Adv Healthc Mater. 2023 Sep;12(23):e2202768. doi: 10.1002/adhm.202202768. Epub 2023 Mar 15.
Tissue engineering aims to generate functional biological substitutes to repair, sustain, improve, or replace tissue function affected by disease. With the rapid development of space science, the application of simulated microgravity has become an active topic in the field of tissue engineering. There is a growing body of evidence demonstrating that microgravity offers excellent advantages for tissue engineering by modulating cellular morphology, metabolism, secretion, proliferation, and stem cell differentiation. To date, there have been many achievements in constructing bioartificial spheroids, organoids, or tissue analogs with or without scaffolds in vitro under simulated microgravity conditions. Herein, the current status, recent advances, challenges, and prospects of microgravity related to tissue engineering are reviewed. Current simulated-microgravity devices and cutting-edge advances of microgravity for biomaterials-dependent or biomaterials-independent tissue engineering to offer a reference for guiding further exploration of simulated microgravity strategies to produce engineered tissues are summarized and discussed.
组织工程旨在生成功能性生物替代品，以修复、维持、改善或替代受疾病影响的组织功能。随着空间科学的快速发展，模拟微重力的应用已成为组织工程领域的一个活跃课题。越来越多的证据表明，微重力通过调节细胞形态、代谢、分泌、增殖和干细胞分化，为组织工程提供了极好的优势。迄今为止，已经有许多在模拟微重力条件下构建具有或不具有支架的生物人工球体、类器官或组织模拟物的成就。本文综述了与组织工程相关的微重力的现状、最新进展、挑战和展望。总结和讨论了当前模拟微重力装置和微重力在依赖生物材料和不依赖生物材料的组织工程中的最新进展，为指导进一步探索模拟微重力策略以产生工程组织提供参考。
