Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA; Roy J. Carver Department of Biomedical Engineering, College of Engineering, University of Iowa, IA 52242, USA.
Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Life Sci Space Res (Amst). 2022 Nov;35:150-157. doi: 10.1016/j.lssr.2022.09.002. Epub 2022 Sep 8.
The spaceflight environment, including microgravity and radiation, may have considerable effects on the health and performance of astronauts, especially for long-duration and Martian missions. Conventional on-ground and in-space experimental approaches have been employed to investigate the comprehensive biological effects of the spaceflight environment. As a class of recently emerging bioengineered in vitro models, tissue chips are characterized by a small footprint, potential automation, and the recapitulation of tissue-level physiology, thus promising to help provide molecular and cellular insights into space medicine. Here, we briefly review the technical advantages of tissue chips and discuss specific on-chip physiological recapitulations. Several tissue chips have been launched into space, and more are poised to come through multi-agency collaborations, implying an increasingly important role of tissue chips in space medicine.
航天环境，包括微重力和辐射，可能对宇航员的健康和表现产生重大影响，尤其是对于长期和火星任务而言。已经采用了常规的地面和空间实验方法来研究航天环境的综合生物效应。作为一类新兴的生物工程体外模型，组织芯片具有占地面积小、潜在自动化以及组织水平生理学的再现等特点，有望为太空医学提供分子和细胞层面的深入了解。在这里，我们简要回顾了组织芯片的技术优势，并讨论了特定的芯片上生理再现。已经有几个组织芯片被发射到太空，并且通过多方合作，更多的组织芯片即将问世，这意味着组织芯片在太空医学中的作用越来越重要。
