Minghui Lu, Changyong Gao, Runtian Zhang, Jianhong Li, Lingling Yuan, Xi Chen
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Tongzhou District Branch, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Front Nutr. 2024 Oct 23;11:1405663. doi: 10.3389/fnut.2024.1405663. eCollection 2024.
Psoriasis is a chronic inflammatory skin disease characterized primarily by erythema and scales, having a wide-ranging impact globally. Previous studies have suggested that dietary consumption habits may influence psoriasis. The objective of this study was to determine the causal relationship between dietary consumption habits and psoriasis using the Mendelian Randomization (MR) approach.
SNP data for 29 dietary consumption habits and psoriasis were obtained from the GWAS catalog database and the FinnGen database, respectively. The Mendelian Randomization analysis was performed using R software, with the 29 dietary consumption habits as the exposure factors and psoriasis as the outcome. Three MR analysis methods-Inverse Variance Weighted (IVW), Weighted Median Estimator (WME), and MR-Egger regression-were employed to study the causal relationship between dietary consumption habits and psoriasis.
The IVW analysis indicated an OR (95%CI) of 0.065 (0.008-0.555), = 0.012, demonstrating a negative correlation between the consumption of dried fruit and psoriasis.
Among the 29 dietary consumption habits analyzed, the intake of dried fruits is a protective factor against psoriasis. Therefore, it is clinically advisable to appropriately increase the intake of dried fruits among patients with psoriasis, serving as a nutritional therapy method in conjunction with pharmacological treatment.
银屑病是一种慢性炎症性皮肤病，主要特征为红斑和鳞屑，在全球具有广泛影响。既往研究提示饮食习惯可能影响银屑病。本研究的目的是采用孟德尔随机化（MR）方法确定饮食习惯与银屑病之间的因果关系。
分别从全基因组关联研究（GWAS）目录数据库和芬兰基因数据库获取29种饮食习惯和银屑病的单核苷酸多态性（SNP）数据。使用R软件进行孟德尔随机化分析，将29种饮食习惯作为暴露因素，银屑病作为结局。采用三种MR分析方法——逆方差加权法（IVW）、加权中位数估计法（WME）和MR-Egger回归法——研究饮食习惯与银屑病之间的因果关系。
IVW分析显示，干果摄入量与银屑病之间呈负相关，比值比（OR，95%置信区间）为0.065（0.008 - 0.555），P = 0.012。
在所分析的29种饮食习惯中，干果摄入是银屑病的一个保护因素。因此，临床上建议银屑病患者适当增加干果摄入量，作为与药物治疗相结合的营养治疗方法。
