Unit of Medical Psychology, Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Frederiksberg, Denmark.
Brain Behav. 2024 Nov;14(11):e70136. doi: 10.1002/brb3.70136.
Cannabis is by far the most widely used and abused drug listed on the Drug Enforcement Administration's Schedule I, which includes drugs with a high potential for abuse. There is evidence of short-term negative effects of cannabis use on cognition, but only a limited number of studies have explored the association between cannabis use and age-related cognitive decline. The aim of the present study was to investigate the relationship between cannabis use and age-related cognitive decline from early adulthood to late midlife.
The study population consisted of 5162 men who had participated in Danish follow-up studies on cognitive aging. These studies included scores on the military intelligence test Børge Prien's Prøve from both the conscription assessment (mean age = 20 years; p1 and p99: 18 and 26 years) and from the follow-up (mean age = 64 years; p1 and p99: 55 and 72 years) as well as extensive data on lifestyle and health from the follow-up questionnaires. The association between cannabis use and age-related cognitive decline was investigated in linear regression models.
Men with a history of cannabis use had less cognitive decline from early adulthood to late midlife compared to men without a history of cannabis use. Among cannabis users, neither age of initiation of cannabis use nor frequent use was significantly associated with a greater age-related cognitive decline.
In a sample of more than 5000 men followed for a mean of 44 years, we found no significant harmful effects of cannabis use on age-related cognitive decline.
大麻是迄今为止在药物管制局的 I 类药物中使用和滥用最多的药物，其中包括具有高度滥用潜力的药物。有证据表明，大麻使用会对认知能力产生短期负面影响，但只有少数研究探讨了大麻使用与与年龄相关的认知能力下降之间的关系。本研究旨在调查从成年早期到中年后期，大麻使用与与年龄相关的认知能力下降之间的关系。
研究人群由 5162 名参加过丹麦认知老化随访研究的男性组成。这些研究包括兵役评估中的军事智力测试 Børge Prien's Prøve 得分（平均年龄为 20 岁；p1 和 p99：18 和 26 岁）和随访中的得分（平均年龄为 64 岁；p1 和 p99：55 和 72 岁），以及来自随访问卷的广泛生活方式和健康数据。使用线性回归模型研究了大麻使用与与年龄相关的认知能力下降之间的关系。
与没有大麻使用史的男性相比，有大麻使用史的男性从成年早期到中年后期的认知能力下降较少。在大麻使用者中，大麻使用的起始年龄或频繁使用均与更大的与年龄相关的认知能力下降无关。
在一项对超过 5000 名男性进行平均随访 44 年的研究中，我们没有发现大麻使用对与年龄相关的认知能力下降有明显的有害影响。
