School of Physical Education and Sports, Central China Normal University, Wuhan, China.
Department of Physical Education, Central South University, Changsha, China.
Front Endocrinol (Lausanne). 2024 Oct 28;15:1449930. doi: 10.3389/fendo.2024.1449930. eCollection 2024.
Metabolic syndrome (MetS) has a close association with cardiovascular diseases. Few studies have investigated the association of Life's Essential 8 (LE8), the updated measurement of cardiovascular health (CVH), with MetS.
The National Health and Nutrition Examination Survey (2005-2018) data was extracted. The LE8 comprised 4 health behaviors (diet, physical activity, nicotine exposure, and sleep health) and 4 health factors [body mass index (BMI), blood lipids, blood glucose, and blood pressure (BP)]. The total LE8 score is the average of 8 metric scores (0-100), categorized into low (0-49), moderate (50-79), and high CVH (80-100) levels. Multivariable logistic regression models, restricted cubic spline models and stratified analyses were performed to examine the relationship between LE8 and MetS.
In this study, a total of 21,543 participants represented 146.6 million non-institutionalized U.S. adults. Following adjustment for various potential covariates, participants who attained a moderate [adjusted odds ratio (AOR) = 0.234, 95% CI: 0.209, 0.262] or a high CVH level (AOR = 0.026, 95% CI: 0.021, 0.032) exhibited an inverse correlation with MetS risks when comparing those with a low CVH level. An inverse linear dose-response relationship between LE8 scores and MetS risks was also identified ( for nonlinearity > 0.05).
LE8 was inversely associated with the risk of MetS. Adhering to LE8 guidelines to sustain a higher CVH level may be beneficial for preventing MetS.
代谢综合征（MetS）与心血管疾病密切相关。很少有研究调查生命的基本 8 项（LE8），即心血管健康的最新衡量标准，与 MetS 的关系。
从国家健康和营养调查（2005-2018 年）中提取数据。LE8 由 4 种健康行为（饮食、身体活动、尼古丁暴露和睡眠健康）和 4 种健康因素[体重指数（BMI）、血脂、血糖和血压（BP）]组成。LE8 的总评分是 8 项指标评分（0-100）的平均值，分为低（0-49）、中（50-79）和高 CVH（80-100）水平。采用多变量逻辑回归模型、限制立方样条模型和分层分析来研究 LE8 与 MetS 之间的关系。
在这项研究中，共有 21543 名参与者代表了 1.466 亿名非机构化的美国成年人。在调整了各种潜在的混杂因素后，与低 CVH 水平相比，达到中（调整后的优势比[OR] = 0.234，95%可信区间[CI]：0.209，0.262）或高 CVH 水平（OR = 0.026，95%CI：0.021，0.032）的参与者与 MetS 风险呈负相关。LE8 评分与 MetS 风险之间也存在反向线性剂量反应关系（非线性>0.05）。
LE8 与 MetS 风险呈负相关。坚持 LE8 指南以维持更高的 CVH 水平可能有助于预防 MetS。
