Jackson Hayley, Oler Eponine, Torres-Calzada Claudia, Kruger Ray, Hira Amandeep Singh, López-Hernández Yamilé, Pandit Devanshi, Wang Jiaxuan, Yang Kellie, Fatokun Omolola, Berjanskii Mark, MacKay Scott, Sajed Tanvir, Han Scott, Woudstra Robyn, Sykes Gina, Poelzer Jenna, Sivakumaran Aadhavya, Gautam Vasuk, Wong Gane, Wishart David S
Department of Biological Sciences, University of Alberta, Edmonton, ABT6G 2E9, Canada.
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, ABT6G 2E9, Canada.
Nucleic Acids Res. 2025 Jan 6;53(D1):D1415-D1426. doi: 10.1093/nar/gkae1056.
MarkerDB (https://markerdb.ca) has become a leading resource for comprehensive information on molecular biomarkers. Over the past 3 years, the database has evolved significantly, reflecting the dynamic landscape of biomarker research and increasing demands from its user community. This year's update, which is called MarkerDB 2.0, introduces key improvements to enhance the database's usability, consistency and the range of biomarkers covered. These improvements include (i) the addition of thousands of new biomarkers and associated health conditions, (ii) the inclusion of many new biomarker types and categories, (iii) upgraded searches and data filtering functionalities, (iv) new features for exploring and understanding biomarker panels and (v) significantly expanded and improved descriptions. These upgrades, along with numerous minor improvements in content, interface, layout and overall website performance, have greatly enhanced MarkerDB's usability and capacity to facilitate biomarker interpretation across various research domains. MarkerDB remains committed to providing a free, publicly accessible platform for consolidated information on a wide range of molecular (protein, genetic, chromosomal and chemical/small molecule) biomarkers, covering diagnostic, prognostic, risk, monitoring, safety and response-related biomarkers. We are confident that these upgrades and updates will improve MarkerDB's user friendliness, increase its utility and greatly expand its potential applications to many other areas of clinical medicine and biomedical research.
MarkerDB（https://markerdb.ca）已成为获取分子生物标志物全面信息的主要资源。在过去三年中，该数据库有了显著发展，反映出生物标志物研究的动态格局以及用户群体不断增长的需求。今年的更新版本MarkerDB 2.0引入了关键改进，以提高数据库的可用性、一致性以及所涵盖的生物标志物范围。这些改进包括：（i）增加了数千种新的生物标志物及相关健康状况；（ii）纳入了许多新的生物标志物类型和类别；（iii）升级了搜索和数据筛选功能；（iv）用于探索和理解生物标志物组合的新功能；（v）大幅扩展并改进了描述内容。这些升级，连同在内容、界面、布局和整体网站性能方面的众多细微改进，极大地提高了MarkerDB的可用性以及在各个研究领域促进生物标志物解读的能力。MarkerDB仍然致力于提供一个免费的、可公开访问的平台，以整合有关广泛分子（蛋白质、基因、染色体和化学/小分子）生物标志物的信息，涵盖诊断、预后、风险、监测、安全性和反应相关的生物标志物。我们相信，这些升级和更新将提高MarkerDB的用户友好性，增加其实用性，并极大地扩展其在许多其他临床医学和生物医学研究领域的潜在应用。
